LRRTM1,富含亮氨酸重复跨膜神经元蛋白1抗体

产品编号HZ-11213R
英文名称LRRTM1
中文名称富含亮氨酸重复跨膜神经元蛋白1抗体
别 名Leucine rich repeat transmembrane neuronal 1; Leucine rich repeat transmembrane neuronal 1 protein; Leucine-rich repeat transmembrane neuronal protein 1; LRRT1_HUMAN; LRRTM1; Lrrtm1 leucine rich repeat transmembrane neuronal 1; OTTHUMP00000194829; 4632401D06Rik; AW125451; FLJ32082.
说 明 书0.1ml 0.2ml
研究领域发育生物学 神经生物学 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
LRRTM1,富含亮氨酸重复跨膜神经元蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human LRRTM1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
LRRTM1,富含亮氨酸重复跨膜神经元蛋白1抗体PubMedPubMed
产品介绍background:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRTM1 (leucine rich repeat transmembrane neuronal 1) is a 522 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and contains ten LRR repeats. Expressed predominately in forebrain tissue, LRRTM1 is thought to be involved in the development of forebrain structures, specifically by influencing axon trafficking, as well as neuronal differentiation and connectivity. Human LRRTM1 shares 96% amino acid identity with its mouse counterpart, suggesting a conserved role between species. Defects in the gene encoding LRRTM1 may be associated with the pathogenesis of several common neurodevelopmental disorders.

Function:
May play a role during the development of specific forebrain structures by influencing neuronal differentiation and connectivity, with a possible role in intracellular trafficking within axons.

LRRTM1,富含亮氨酸重复跨膜神经元蛋白1抗体Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity).

Tissue Specificity:
Predominantly expression in forebrain regions including thalamus and cerebral cortex.

Similarity:
Belongs to the LRRTM family.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Gene ID:
347730

Database links:
Entrez Gene: 347730 Human
Entrez Gene: 74342 Mouse
Omim: 610867 Human
SwissProt: Q86UE6 Human
SwissProt: Q8K377 Mouse
Unigene: 591580 Human
Unigene: 292568 Mouse

LRRTM1,富含亮氨酸重复跨膜神经元蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.