GDN,胶质源性连接蛋白抗体

产品编号HZ-9845R
英文名称GDN
中文名称胶质源性连接蛋白抗体
别 名Glia derived nexin; Protease inhibitor 7; GDN; GDN_HUMAN; Glia-derived nexin; P17 antibody Peptidase inhibitor 7; Pi-7; Plasminogen activator inhibitor type 1, member 2; PN-1; PN1; PNI; Protease nexin 1; Protease nexin I; Serpin E2; Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; SERPINE 2; Serpine2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
GDN,胶质源性连接蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GDN/SERPINE2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GDN,胶质源性连接蛋白抗体PubMedPubMed
产品介绍background:
The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer’s disease.

Function:
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Subcellular Location:
Secreted, extracellular space.

Similarity:
Belongs to the serpin family.

Database links:
Entrez Gene: 2668 Human
Entrez Gene: 14573 Mouse
Entrez Gene: 25453 Rat
Omim: 600837 Human
SwissProt: P39905 Human
SwissProt: P48540 Mouse
SwissProt: Q07731 Rat
Unigene: 248114 Human
Unigene: 4679 Mouse
Unigene: 53970 Rat

GDN,胶质源性连接蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.