FITC标记的钙粘蛋白21抗体
产品名称： FITC标记的钙粘蛋白21抗体
英文名称： Anti-PCDH21/FITC
产品编号： HZ-13731R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDH21/FITC Conjugated antibody
FITC标记的钙粘蛋白21抗体
| 英文名称 | Anti-PCDH21/FITC |
| 中文名称 | FITC标记的钙粘蛋白21抗体 |
| 别 名 | Protocadherin 21; Cadherin-related family member 1; CDHR1; CDHR1_HUMAN; CORD15; DKFZp434A132; KIAA1775; MT protocadherin; PCDH 21; PCDH21; PCDH21 protein; Photoreceptor cadherin; prCAD; Protocadherin-21; RP65. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 91kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDH21 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH21 (protocadherin 21), also known as PRCAD, is an 859 amino acid single-pass membrane protein that localizes to the outer segments of photoreceptor cells and contains six cadherin domains. Existing as multiple alternatively spliced isoforms, PCDH21 functions as a calcium-dependent cell adhesion protein that is thought to be required for the structural integrity of photoreceptor cells and may be involved in the formation and maintenance of neuronal networks. Function: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells. Subcellular Location: Cell membrane. Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region. Post-translational modifications: Undergoes proteolytic cleavage; produces a soluble 95 kDa N-terminal fragment and a 25 kDa cell-associated C-terminal fragment. Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 92211 Human Omim: 609502 Human SwissProt: Q96JP9 Human Unigene: 137556 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原钙粘附素是钙粘附素样细胞粘附蛋白的一个大家族，参与建立和维持大脑中的神经元连接。原钙粘蛋白基因簇有三个，分别命名为α、β和γ，它们都包含多个串联排列的基因。PCDH21（原钙粘蛋白21），又称PRCAD，是一种859个氨基酸的单程膜蛋白，定位于感光细胞的外段，包含六个钙粘蛋白结构域。PCDH21作为多种可选择的剪接异构体存在，其作为钙依赖性细胞粘附蛋白发挥作用，该蛋白被认为对光感受器细胞的结构完整性是必需的，并且可能参与神经元网络的形成和维持。