雌激 素受体信号转导PCR芯片可用于研究参与雌激 素受体（ER）的激活和响应的84个关键基因的表达。雌激 素受体是对发育，生长和繁殖有重要作用的类固醇激 素受体。研究较清楚的ER，α和β，在细胞核内相互调控，启动靶基因的转录。ER也可以与细胞膜连接，在那里它们激活下游信号通路。ER在女性器官癌症，尤其是乳腺癌有重要作用。由于组织特异性的ER反应不同，ER信号传导的机制尚未完全了解，这取决于兴奋剂或拮抗剂。ER信号通路对于哺乳动物系统以外的其他女性器官也是很重要的。例如，ER参与神经系统的发育，雌激 素在防止心血管疾病和骨质疏松症上面起到一定的保护作用，虽然这些过程的确切机制正在研究。该芯片包括ER及其共同调控因子和相互作用的蛋白质和下游靶基因。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测参与雌激 素信号通路的基因表达。
Estrogen Receptors: ESR1 (ERα), ESR2 (ERβ), GPER (GPR30). ER Cofactors & Interacting Proteins: AHR, BCAR1, BRCA1, CAV1, CCND1, EFNA5, ESR1, ESR2, HSP90AA1, IGF1, MED1, MTA1, NCOA1, NCOA2, NCOA3, NCOR1, NCOR2, NR0B1, NR0B2, NRIP1, PELP1, PGR, PHB2, SAFB, TFF1 (PS2), VDR. Estrogen Receptor Target Genes: Female Sex Differentiation: BCL2L1 (BCL-X), FST, NRIP1, PGR, VEGFA, WNT4, WNT5A. Male Sex Differentiation: BCL2L1 (BCL-X), CCND1, CYP19A1, WNT4, WNT5A. Ovulation Cycle: BCL2L1 (BCL-X), BMP4, ERBB2 (HER2), FST, NRIP1, PGR, TGFB3, VEGFA, WNT5A. Pregnancy: FOS, JUNB, PGR, PTGS2 (COX2), SNAI1 (Snail), SOCS3, SPP1 (Osteopontin), TGFB3, WNT4. Mammary Gland Development: BMP4, CAV1, CCND1, ERBB2 (HER2), ERBB3, IGFBP5, IRS1, NR3C1 (GRL), PGR, PTCH1, TGFB3, VEGFA, WNT4, WNT5A. Cardiovascular System Development: C3, CAV1, CCL2 (MCP-1), EGR3, ERBB2 (HER2), ERBB3, JUNB, KLK3, MMP9 (Gelatinase B), NRP1, PTCH1, PTGS2 (COX2), RARA, SOCS3, TGFA, THBS1, VEGFA, WNT4, WNT5A. Nervous System Development: APBB1, BDNF, CCL2 (MCP-1), CITED2, CKB, CYP19A1, EGR3, ERBB2 (HER2), ERBB3, FOS, FOXA1, L1CAM, LGALS1, NAB2, NR2F6, NR3C1 (GRL), NRP1, PTCH1, S100A6, SPP1 (Osteopontin), VEGFA, WNT4, WNT5A. Bone Development: BMP4, BMP7, IGF1, IGFBP5, JUNB, MMP9 (Gelatinase B), NAB2, PTGS2 (COX2), SNAI1 (SNAIL), SPP1 (Osteopontin), TGFB3, WNT4, WNT5A. Growth Regulation: BMP7, CTGF, EBAG9, ERBB2 (HER2), IGFBP4, IGFBP5, NOV, NRP1, PTCH1, SOCS3, SPP1 (Osteopontin), WISP2, WNT5A. Transcription: EGR3, FOS, FOXA1, JUNB, MAFF, MYC, NCOA1, NCOA3, NR3C1 (GRL), NR5A2, NRIP1, PGR, RARA, SNAI1 (Snail), XBP1. Other Genes: AKAP1, CTSD, CYP1A1, G6PD, LPL, LTBP1, PDZK1, RALA, TFF1 (PS2).