FITC标记的激肽释放酶9抗体（舒血管素9）
产品名称： FITC标记的激肽释放酶9抗体（舒血管素9）
英文名称： Anti-KLK9/FITC
产品编号： HZ-1967R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-KLK9/FITC Conjugated antibody
FITC标记的激肽释放酶9抗体（舒血管素9）
| 英文名称 | Anti-KLK9/FITC |
| 中文名称 | FITC标记的激肽释放酶9抗体（舒血管素9） |
| 别 名 | Kallikrein 8; Kallikrein 9; Kallikrein L3; Kallikrein Like 3; Kallikrein like protein 3; kallikrein related peptidase 9; Kallikrein-9; Kallikrein-like protein 3; Kallikrein8; Kallikrein9; KLK 8; KLK 9; KLK L3; KLK-L3; KLK8; KLK9; KLK9_HUMAN; KLKL 3; KLKL3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 激酶和磷酸酶 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLK9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Kallikrein 9, also known as Kallikrein-Like 3 (KLK-L3), is a chymotrypsin-like serine proteinase. Kallikrein 9 was discovered as the locus for kallikreins on chromosome 19 was more fully mapped and found by similarity to the other tissue kallikreins. Kallikrein 9 has been found in the ovary, thymus, testis, prostate, skin, breast and neuronal tissues and is made by many cell lines in culture. Kallikrein 9 levels in breast cancer and uterine cancer patients have been reported to drop as the disease progresses, thus hK9 might be considered a favorable prognostic marker. Different splice variants of hK9 have been reported, although it is not yet known if they produce functional proteins. The full length Kallikrein 9 encodes for a 250 amino acid protein, with a predicted mass of 27.5 kDa and a pI of 7.53. The 234 amino acid form predicts a protein of 26 kDa with a pI of 9.76 and this quite basic pI might give the shorter form a very different function or localization. The shorter sequence also diverges before the catalytic serine residue, making it unlikely to be proteolytically active. Pre-pro-kallikrein 9 has the 17 amino acid signal sequence is removed before secretion, and the Pro-kallikrein 9 is activated to Kallikrein 9 by removal of the 5 amino acid propeptide domain. Subcellular Location: Secreted (Probable). Tissue Specificity: Skin, thymus, trachea, cerebellum and spinal cord. Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 284366 Human Omim: 605504 Human SwissProt: Q9UKQ9 Human Unigene: 448942 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. KLK9目前认为是卵巢癌 宫颈癌 子宫内膜癌等其他肿瘤,很有意义的标志物。激肽释放酶KLK是激肽系统的主要限速酶，它是一组存在于多数组织和体液中的丝氨酸蛋白酶，是一种肽链内切酶。KLK又称血管舒缓素，包括15个家族成员。在不同的组织中广泛表达,具有蛋白水解酶的活性。它特异性的在碳末端切割底物肽，可裂解激肽原释放具有活性的激肽，由激肽发挥对心血管系统及肾脏功能的调节作用。 组织KLK是一个大的基因家族，主要分布在肺、肾、血管、脑、肾上腺组织，为一种中等大小的糖蛋白。 |
激肽释放酶9，所以称为激肽释放酶样3（L3，KLK）是丝氨酸蛋白酶样蛋白酶。激肽释放酶9基因（激肽释放酶被发现为更完全映射在染色体19和/或由其他组织激肽释放酶的相似性。激肽释放酶9已被发现在卵巢，睾丸，胸腺，前列腺，乳腺癌，皮肤，神经和组织是由许多细胞系的文化。激肽释放酶9的水平在乳腺癌和子宫癌患者已经报告的疾病滴为O，因此可以被视为一hk9有利的预后标志物。不同的剪接变体（hk9已经报告，虽然它是已知的，如果他们还没有产生功能性蛋白。激肽释放酶的全长9 encodes for a 250个氨基酸的预测蛋白，一个体重27.5 kDa的和PI（A）7.53。在234氨基酸形式A和26 kDa的蛋白有一个很基本的PI和PI（9.76这可能给一个较短的形式不同的功能或本地化。因此，在diverges短序列的催化丝氨酸残基，使它不可能的蛋白水解活动。预激肽释放酶9有一个17氨基酸信号序列被删除之前，亲激肽释放酶的分泌和激活激肽释放酶9和9是由排出的5个氨基酸域组织纤维化标志物。