FITC标记的形态发生紊乱关联激活因子2抗体
产品名称： FITC标记的形态发生紊乱关联激活因子2抗体
英文名称： Anti-DAAM2/FITC
产品编号： HZ-12430R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DAAM2/FITC Conjugated antibody
FITC标记的形态发生紊乱关联激活因子2抗体
| 英文名称 | Anti-DAAM2/FITC |
| 中文名称 | FITC标记的形态发生紊乱关联激活因子2抗体 |
| 别 名 | DAAM2; DAAM2_HUMAN; Disheveled-associated activator of morphogenesis 2; dishevelled associated activator of morphogenesis 2; dJ90A20A.1; KIAA0381; MGC90515; RP1 278E11.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 123kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DAAM2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DAAM2 is a widely expressed 1,068 amino acid protein that contains one DAD domain, one FH1 domain, one FH2 domain and one GBD domain, through which it may play a role in Wnt/Frizzled-associated signaling events. The gene encoding DAAM2 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. Tissue Specificity: Expressed in most tissues examined. Similarity: Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. Database links: Entrez Gene: 23500 Human
Entrez Gene: 76441 Mouse Entrez Gene: 316201 Rat Omim: 606627 Human SwissProt: Q86T65 Human SwissProt: Q80U19 Mouse Unigene: 357128 Human Unigene: 718492 Human Unigene: 211275 Mouse Unigene: 129337 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DAAM2是一种广泛表达的1068个氨基酸蛋白，含有一个DAD结构域、一个FH1结构域、一个FH2结构域和一个GBD结构域，通过该结构域，DAAM2可能在Wnt/Frizzled相关信号转导事件中发挥作用。编码DAAM2的基因定位于人类6号染色体，其中包含1.7亿个碱基对，占人类基因组的近6%。6号染色体q臂部分缺失与早期发病的肠癌有关，提示存在癌症易感位点。此外，迟发性皮肤卟啉症、帕金森病、Stickler综合征和双相情感障碍的易感性都与映射到6号染色体的基因有关。