ASB10,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体

产品编号HZ-4653R
英文名称ASB10
中文名称含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体
别 名Ankyrin repeat and SOCS box containing 10; Ankyrin repeat and SOCS box protein 10; ASB 10; ASB-10; ASB10; ASB10_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域细胞生物
抗体来源Rabbit
ASB10,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ASB10.
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ASB10,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体PubMedPubMed
产品介绍background:
ASB10 is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling (SOCS) family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box couples the suppressor of cytokine signalling proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.

Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Similarity:
Contains 7 ANK repeats.
Contains 1 SOCS box domain.

Database links:
UniProtKB/Swiss-Prot: Q8WXI3.2

ASB10,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.