FITC标记的ETS1相关蛋白2抗体
产品名称： FITC标记的ETS1相关蛋白2抗体
英文名称： Anti-ETS1 associated protein II/FITC
产品编号： HZ-5164R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ETS1 associated protein II/FITC Conjugated antibody
FITC标记的ETS1相关蛋白2抗体
| 英文名称 | Anti-ETS1 associated protein II/FITC |
| 中文名称 | FITC标记的ETS1相关蛋白2抗体 |
| 别 名 | EAP 2; EAP II; EAP2; EAPII; ETS 1 associated protein 2; ETS 1 associated protein II; ETS1 associated protein 2; ETS1-associated protein 2; ETS1-associated protein II; tdp2; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; TTRAP; TYDP2_HUMAN; Tyr DNA phosphodiesterase 2; Tyr-DNA phosphodiesterase 2; Tyrosyl DNA phosphodiesterase 2; Tyrosyl-DNA phosphodiesterase 2; 5''-Tyr-DNA phosphodiesterase; 5''-tyrosyl-DNA phosphodiesterase; AD 022; AD022; MGC111021; MGC9099. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ETS1 associated protein II/EAPII |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation. Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation. Subunit: Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4. Subcellular Location: Nucleus. Nucleus, PML body. Tissue Specificity: Widely expressed. Similarity: Belongs to the CCR4/nocturin family. Database links: Entrez Gene: 51567 Human Omim: 605764 Human SwissProt: O95551 Human Unigene: 728795 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DNA修复酶，可以通过水解5′-磷酸二酯键从DNA中去除多种共价加合物，从而产生具有5’磷酸的游离DNA。催化DNA和拓扑异构酶2（Top2）活性位点酪氨酸残基之间的死端复合物的水解。在DNA双链断裂（DSBS）上，由于辐射和自由基的DNA损伤，5′-磷酸甘油酯在5′末端上水解。5’-酪氨酸DNA磷酸二酯酶活性可使Top2诱导的DSBS修复而不需要核酸酶活性，从而产生一个“干净”的DSB，其具有5’-磷酸末端，准备用于结扎。也有3’-酪氨酰DNA磷酸二酯酶活性，但效率较低，比TDP1慢得多。也可作为ETS1的负调控因子，并可抑制核因子-κB活化。