FITC标记的异构核糖核蛋白E1抗体
产品名称： FITC标记的异构核糖核蛋白E1抗体
英文名称： Anti-PCBP1/FITC
产品编号： HZ-19907R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCBP1/FITC Conjugated antibody
FITC标记的异构核糖核蛋白E1抗体
| 英文名称 | Anti-PCBP1/FITC |
| 中文名称 | FITC标记的异构核糖核蛋白E1抗体 |
| 别 名 | Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX; nucleic acid binding protein sub 2.3; Nucleic acid- binding protein SUB2.3; Nucleic acid-binding protein SUB2.3; PCBP1; PCBP1_HUMAN; poly(rC) binding protein 1; poly(rC)-binding protein 1; rCbinding protein 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCBP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008] Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Subcellular Location: Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. Tissue Specificity: Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. Post-translational modifications: Phosphorylated; lowers poly(rC)-binding activity. Similarity: Contains 3 KH domains. Database links: Entrez Gene: 5093 Human Entrez Gene: 23983 Mouse Entrez Gene: 500242 Rat Omim: 601209 Human SwissProt: Q5E9A3 Cow SwissProt: Q15365 Human SwissProt: P60335 Mouse SwissProt: O19048 Rabbit Unigene: 2853 Human Unigene: 274146 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
这种无内含子基因被认为是由完全处理的PCBP-2 mRNA的逆转录转位产生的。该基因和PCBB-2具有对偶序列（PCBP3和PCBP4），它们被认为是由于整个基因的重复事件而出现的。由该基因编码的蛋白质似乎是多功能的。它与PCBP-2和HNRNPK对应的主要细胞聚（RC）结合蛋白。它包含三个K-同源（KH）结构域，可能参与RNA结合。该编码蛋白和PCBB-2还通过与IRES的茎环IV的序列特异性相互作用，作为脊髓灰质炎病毒RNA的翻译辅活化子，并通过与它的5′端三叶草结构结合来促进脊髓灰质炎病毒RNA的复制。它还参与翻译控制15-脂氧合酶mRNA、人乳头瘤病毒16型L2 mRNA和A型肝炎病毒RNA。编码蛋白还被建议在序列特异性α-珠蛋白mRNP复合物的形成中发挥作用，该复合物与α-珠蛋白mRNA的稳定性相关。[ RefSeq，JUL 2008 ]