NNP1,新型核蛋白质1抗体

产品编号HZ-9300R
英文名称NNP1
中文名称新型核蛋白质1抗体
别 名NNP 1; NNP-1; NNP1; Nnp1 homolog nucleolar protein; Novel nuclear protein 1; Nucleolar protein Nop52; Protein NNP 1; Protein NNP1; Ribosomal RNA processing 1 homolog; Ribosomal RNA processing protein 1 homolog A; rrp1; RRP1 like protein; RRP1-like protein; RRP1_HUMAN; RRP1A.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 细胞分化 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
NNP1,新型核蛋白质1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NNP1/RRP1 like protein
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NNP1,新型核蛋白质1抗体PubMedPubMed
产品介绍background:
Novel nuclear protein 1 (NNP-1), also known as RRP1-like protein or Nucleolar protein Nop52, is a 461 amino acid protein belonging to the RRP1 family. Localized to the nucleolus, NNP-1 has simian virus 40-type and bipartite nuclear localization signals and four coiled-coil domains within its C-terminal region. NNP-1 has been found to play an important role in the generation of 28S rRNA in the late processing steps of ribosome biogenesis. At the end of mitosis, nucleolar proteins assemble in a sequential order during the rebuilding of the nucleolus. NNP-1 assembles after Fibrillarin and C23, and simultaneously with B23 and POP1 in the prenucleolar body pathway.

Function:
Plays a critical role in the generation of 28S rRNA.

Subunit:
Interacts with C1QBP.

Subcellular Location:
Nucleus, nucleolus.

Tissue Specificity:
Ubiquitously expressed in fetal and adult tissues.

NNP1,新型核蛋白质1抗体Similarity:
Belongs to the RRP1 family.

Gene ID:
23076

Database links:
Entrez Gene: 23076 Human
Entrez Gene: 72462 Mouse
Entrez Gene: 309673 Rat
Omim: 610654 Human
SwissProt: Q14684 Human
SwissProt: Q91YK2 Mouse
Unigene: 654727 Human
Unigene: 54275 Rat

NNP1,新型核蛋白质1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.