TBL1Y,转导β样蛋白1抗体

产品编号HZ-8164R
英文名称TBL1Y
中文名称转导β样蛋白1抗体
别 名Y-linked; F-box-like/WD repeat-containing protein TBL1Y; TBL1; TBL1Y; TBL1Y_HUMAN; Transducin (beta) like 1, Y linked; Transducin beta-like 1; Transducin beta-like protein 1Y; Transducin-beta-like protein 1; Transducin-beta-like protein 1, Y-linked.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
TBL1Y,转导β样蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from huamn TBL1Y
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TBL1Y,转导β样蛋白1抗体PubMedPubMed
产品介绍background:
FunctionF-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.

Function:
F-box-like protein involved in the recruitment of theubiquitin/19S proteasome complex to nuclear receptor-regulatedtranscription units. Plays an essential role in transcriptionactivation mediated by nuclear receptors. Probably acts as integralcomponent of corepressor complexes that mediates the recruitment ofthe 19S proteasome complex, leading to the subsequent proteasomaldegradation of transcription repressor complexes, thereby allowingcofactor exchange (By similarity).

Subunit:
Probable component of the N-Cor repressor complex andsome E3 ubiquitin ligase complex (By similarity).

Subcellular Location:
Nucleus (By similarity).

Tissue Specificity:
Fetal brain and prostate.

TBL1Y,转导β样蛋白1抗体Similarity:
Belongs to the WD repeat EBI family.
Contains 1 F-box-like domain.
Contains 1 LisH domain.
Contains 8 WD repeats.

Database links:
UniProtKB/Swiss-Prot: Q9BQ87.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.