AMACR/p504S抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
AMACR/p504S抗体

AMACR/p504S抗体

商家询价

产品名称： AMACR/p504S抗体

英文名称： AMACR/p504SAntibody

产品编号： XY15918-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 AMACR/P504S抗体

Applications
Tested Applications: ELISA, IHC, WB
Specificity Reaction: Human; Other species are not tested.Please decide the specificity by homology
Positive WB detected in Multi-cells
Positive IHC detected in Human prostate cancer tissue, human renal cell carcinoma tissue
Recommended dilution WB : 1:500-1:5000
IHC : 1:20-1:200
 AMACR/P504S抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev1NextView more validation data
  • 15918-1-AP;multi-cellsWB result of 15918-1-AP(anti-P504S,AMACR) from Dr. Soory.
  • 15918-1-AP;human prostate cancer tissueImmunohistochemical of paraffin-embedded human prostate cancer using 15918-1-AP(p504S,AMACR antibody) at dilution of 1:50 (under 10x lens). Heat mediated antigen retrieved with Citric acid buffer, pH6.0
  • 15918-1-AP;human prostate cancer tissueImmunohistochemical of paraffin-embedded human prostate cancer using 15918-1-AP(p504S,AMACR antibody) at dilution of 1:50 (under 40x lens). Heat mediated antigen retrieved with Citric acid buffer, pH6.0
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information AMACR/P504S抗体
Immunogen: AMACR/p504S fusion protein ag8720 Full Name: Alpha-methylacyl-CoA racemase
Caculated Molecular
Weight:		 382aa,42 kDa Observed Molecular 
Weight:		 42 kDa
GenbankNo BC009471 GeneID: 23600
Symbol AMACR Synonyms 2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE
Background

AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4). AMACR/P504S抗体

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