FITC标记的蛋白酶体26S亚基ATP酶3相互作用蛋白抗体
产品名称： FITC标记的蛋白酶体26S亚基ATP酶3相互作用蛋白抗体
英文名称： Anti-PSMC3IP/FITC
产品编号： HZ-19464R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PSMC3IP/FITC Conjugated antibody
FITC标记的蛋白酶体26S亚基ATP酶3相互作用蛋白抗体
| 英文名称 | Anti-PSMC3IP/FITC |
| 中文名称 | FITC标记的蛋白酶体26S亚基ATP酶3相互作用蛋白抗体 |
| 别 名 | 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Human immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome (prosome macropain) 26S subunit ATPase 3; Proteasome 26S ATPase subunit 3; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; PRS6A_HUMAN; PSMC 3; PSMC3; Tat binding protein 1; TAT-binding protein 1; TBP-1; TBP1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSMC3IP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011] Function: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in testis and colon. Post-translational modifications: PTM: Phosphorylated by PKA, PKC and MAPK. DISEASE: Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the HOP2 family. Database links: ntrez Gene: 29893 Human Entrez Gene: 19183 Mouse Entrez Gene: 140938 Rat Omim: 608665 Human SwissProt: Q9P2W1 Human SwissProt: O35047 Mouse SwissProt: Q91ZY6 Rat Unigene: 383019 Human Unigene: 18344 Mouse Unigene: 144650 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因编码在减数分裂重组中起作用的蛋白质。它是PSMC3IP/MND1复合物的一个亚基，它与PSMC3/TBP1相互作用，在减数分裂过程中刺激DMC1和RAD51介导的链交换。该基因编码的蛋白还可以协同激活由雌激素、雄激素、糖皮质激素、孕酮和甲状腺核受体介导的配体驱动转录。该基因突变导致XX女性性腺发育不全。该基因的选择性剪接导致多个TrsCl