磷酸化钙调磷酸酶B亚基B1抗体
产品名称： 磷酸化钙调磷酸酶B亚基B1抗体
英文名称： Phospho-Calcineurin B (Tyr106)
产品编号： hz-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
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Rabbit Anti-Phospho-Calcineurin B (Tyr106) antibody
| 产品编号 | hz-10342R |
| 英文名称 | Phospho-Calcineurin B (Tyr106) |
| 中文名称 | 磷酸化钙调磷酸酶B亚基B1抗体 |
| 别 名 | Calcineurin B (phospho Y106); Calcineurin B (phospho Tyr106); p-Calcineurin B (Tyr106); Calcineurin subunit B type 1; CALNB1; CANB1_HUMAN; Cna2; CNB; CNB1; OTTHUMP00000201960; OTTHUMP00000201961; Ppp3r1; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; alpha isoform (calcineurin B, type I); calcineurin B, type I (19kDa); protein phosphatase3 (formerly2B), regulatory subunit B, alpha isoform antibody Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I); Protein phosphatase 3 regulatory subunit B alpha; Protein phosphatase 3 regulatory subunit B alpha isoform 1. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Fruit Fly, Danio rerio |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Calcineurin B around the phosphorylation site of Tyr106:51-150/170 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-A alpha, PP2B-A Beta and PP2B-A Gamma. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2. Function: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Subunit: Composed of a catalytic subunit (A) and a regulatory subunit (B). Similarity: Belongs to the calcineurin regulatory subunit family. Contains 4 EF-hand domains. Gene ID: 5534 Database links: Entrez Gene: 5534 Human Entrez Gene: 19058 Mouse Entrez Gene: 29748 Rat Omim: 601302 Human SwissProt: P63098 Human SwissProt: Q63810 Mouse SwissProt: P63100 Rat Unigene: 280604 Human Unigene: 41840 Mouse Unigene: 42903 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |