FITC标记的LYNX1蛋白抗体
产品名称： FITC标记的LYNX1蛋白抗体
英文名称： Anti-LYNX1/FITC
产品编号： HZ-18569R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LYNX1/FITC Conjugated antibody
FITC标记的LYNX1蛋白抗体
| 英文名称Anti-LYNX1/FITC中文名称FITC标记的LYNX1蛋白抗体别 名Ly-6/neurotoxin-like protein 1; Ly6/neurotoxin 1; LYNX1; LYNX1_HUMAN; Secreted Ly6/uPAR related protein 2; SLURP2. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域细胞生物 免疫学 神经生物学 细胞膜受体 淋巴细胞 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, 产品应用ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量12kDa性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human LYNX1亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha4beta2 nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha4beta2 nAChRs By similarity. Prevents plasticity in the primary visual cortex late in life By similarity. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis. Subunit: Isoform 2 interacts with nAChRs, including alpha4beta2 (CHRNA4/CHRNB2) and alpha7 (CHRNA7) By similarity. Competes with alpha-bungarotoxin for nAChR alpha7 binding. Isoform 3 may interact with heteropentameric nAChRs expressed by keratinocytes. Subcellular Location: Cell membrane. Tissue Specificity: Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up-regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level). Similarity: Contains 1 UPAR/Ly6 domain. Database links: Entrez Gene: 66004 Human Entrez Gene: 23936 Mouse Entrez Gene: 300018 Rat Omim: 606110 Human SwissProt: Q9BZG9 Human SwissProt: Q9WVC2 Mouse Unigene: 158665 Human Unigene: 257067 Mouse Unigene: 32045 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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该基因编码Ly-6/神经毒素基因家族的成员，Ly-6/神经毒素基因家族是一组淋巴细胞抗原，通过糖基磷脂酰肌醇锚附着在细胞表面，并且具有独特的结构，显示出具有特征间隔模式的保守的8-10半胱氨酸残基。功能分析表明，该蛋白不是配体或神经递质，但在乙酰胆碱存在下具有增强烟碱型乙酰胆碱受体功能的能力。该基因也可能在寻常型银屑病的发病机制中发挥作用。另外，已经识别了编码不同亚型的剪接变异体。[ RefSeq，JUL 2008 ]