FITC标记的脯氨酸脱氢酶抗体
产品名称： FITC标记的脯氨酸脱氢酶抗体
英文名称： Anti-PRODH/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PRODH/FITC Conjugated antibody
FITC标记的脯氨酸脱氢酶抗体
| 英文名称 | Anti-PRODH/FITC |
| 中文名称 | FITC标记的脯氨酸脱氢酶抗体 |
| 别 名 | HSPOX2; P53 induced gene 6 protein; PIG6; PRODH 1; PRODH 2; PRODH1; PRODH2; Proline dehydrogenase; proline dehydrogenase (oxidase) 1; proline dehydrogenase (proline oxidase); Proline oxidase, mitochondrial precursor; SCZD4; TP53I6; tumor protein p53 inducible protein 6; PROD_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 68kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRODH |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Proline oxidase catalyzes the conversion of proline to pyrroline-5-carboxylate, or P5C during the degradation of the amino acid Proline. Defects in PRODH are the cause of hyperprolinemia type 1, a disorder characterized by elevated serum proline levels. Defective PRODH may be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome and may be associated with susceptibility to schizophrenia 4 (SCZD4). Function: Converts proline to delta-1-pyrroline-5-carboxylate. Subcellular Location: Mitochondrion matrix. Tissue Specificity: Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas. DISEASE: Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Similarity: Belongs to the proline oxidase family. Database links: Entrez Gene: 5625 Human Entrez Gene: 19125 Mouse Entrez Gene: 680409 Rat Omim: 606810 Human SwissProt: O43272 Human SwissProt: Q9WU79 Mouse Unigene: 517352 Human Unigene: 28456 Mouse Unigene: 153570 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
脯氨酸氧化酶催化脯氨酸到啉-5-羧酸盐或P5C在氨基酸脯氨酸降解过程中的转化。PRODH中的缺陷是高脯氨酸血症1型的病因，其特征是血清脯氨酸水平升高。有缺陷的PRDH可能参与精神分裂症和行为学表型与22q11心脏病和DigeoGGE综合征，并可能与精神分裂症易感性4（SCZD4）有关。