ASB17,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族17抗体

产品编号HZ-9135R
英文名称ASB17
中文名称含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族17抗体
别 名Ankyrin repeat and SOCS box containing 17; Ankyrin repeat and SOCS box protein 17; ASB-17; ASB17; ASB17_HUMAN.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
ASB17,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族17抗体交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ASB17
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ASB17,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族17抗体PubMedPubMed
产品介绍background:
Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-17 is a 295 amino acid member of this family. ASB-17 contains one ankyrin repeat and one SOCS box domain. ASB-17 is thought to be a substrate-recognition subunit of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination of target proteins and their subsequent proteasomal degradation.

Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Subcellular Location:

Similarity:
Contains 1 ANK repeat.
Contains 1 SOCS box domain.

ASB17,含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族17抗体Database links:
UniProtKB/Swiss-Prot: Q8WXJ9.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.