FITC标记的剑蛋白p60亚基A1抗体
产品名称： FITC标记的剑蛋白p60亚基A1抗体
英文名称： Anti-KATNA1/FITC
产品编号： HZ-9308R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-KATNA1/FITC Conjugated antibody
FITC标记的剑蛋白p60亚基A1抗体
| 产品编号 | bs-9308R-FITC |
| 英文名称 | Anti-KATNA1/FITC |
| 中文名称 | FITC标记的剑蛋白p60亚基A1抗体 |
| 别 名 | Katanin p60 A1; Katanin p60 ATPase containing subunit A1; Katanin p60 ATPase-containing subunit A1; Katanin p60 subunit A1; KATNA1; KTNA1_HUMAN; p60 katanin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KATNA1/Katanin p60 A1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Microtubules are polymers of alpha and beta subunits that form the mitotic spindle and assist in the organization of membranous organelles during interphase. Katanin p60 A1, also known as KATNA1, is a 491 amino acid protein that belongs to the AAA ATPase family and is involved in microtubule regulation. Localized to the cytoplasm and to the centrosome, Katanin p60 A1 functions to sever and disassemble microtubules in an ATP-dependent manner, thus promoting the rapid reorganization of cellular microtubule arrays and playing an important role in microtubule release from the centrosome after nucleation. Katanin p60 A1, which exists as two alternatively spliced isoforms, can homooligomerize into hexameric rings whose activity is stimulated by the presence of microtubules. Function: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth (By similarity). Subunit: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. Post-translational modifications: Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted to proteasomal degradation. Similarity: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. Database links: Entrez Gene: 11104 Human Entrez Gene: 23924 Mouse Omim: 606696 Human SwissProt: O75449 Human SwissProt: Q9WV86 Mouse Unigene: 450175 Human Unigene: 28127 Mouse Unigene: 421297 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
微管是α和β亚基的聚合物，它们形成有丝分裂纺锤体，并协助间期膜细胞器的组织。KATAN P60A1，又称KATN1，是属于AAA ATPase家族的491氨基酸蛋白，参与微管的调控。KATAN P60A1的功能是以ATP依赖的方式切断和分解微管，从而促进细胞微管阵列的快速重组，并在细胞核后的中心体微管释放中发挥重要作用。在。KATANIN P60A1，作为两个交替拼接的异构体存在，可以同质齐聚成六聚体环，其活性受微管的存在刺激。