FITC标记的脑钙粘蛋白12抗体
产品名称： FITC标记的脑钙粘蛋白12抗体
英文名称： Anti-CDH12/FITC
产品编号： HZ-13715R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CDH12/FITC Conjugated antibody
FITC标记的脑钙粘蛋白12抗体
| 英文名称 | Anti-CDH12/FITC |
| 中文名称 | FITC标记的脑钙粘蛋白12抗体 |
| 别 名 | Br cadherin; BR-cadherin; Brain cadherin; CAD12_HUMAN; cadherin 12 (N cadherin 2); Cadherin 12; Cadherin 12 precursor; Cadherin 12 type 2 (N cadherin 2); Cadherin 12 type 2; Cadherin neural type 2; Cadherin-12; CDH12; CDHB; FLJ34857; N cadherin 2; N-cadherin 2; Neural type cadherin 2; Neuronal cadherin 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 82kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDH12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morpho-genesis (1-4). Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity (5,6). The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin b, to regulate cadherin function (7). BR-cadherin (for brain-cadherin, also designated cadherin-12 or N-cadherin 2) is expressed specifically in neurons in the central nervous system and is thought to be involved in neuronal development (8). Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Subcellular Location: Cell membrane. Tissue Specificity: Brain. Similarity: Contains 5 cadherin domains. Database links: Entrez Gene: 1010 Human Omim: 600562 Human SwissProt: P55289 Human Unigene: 113684 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
钙粘附素是钙依赖性粘附分子家族，其功能是介导对维持组织结构和形态发生至关重要的细胞-细胞结合(1-4)。钙粘蛋白每个在氨基末端都含有一个大的细胞外结构域，其特征是一系列五个同源重复，其中最远端被认为负责结合特异性（5，6）。相对短的羧基末端，胞内结构域与各种细胞质蛋白相互作用，包括连环蛋白b，以调节钙粘蛋白功能（7）。BR-cadherin(脑钙粘蛋白，也称为钙粘蛋白-12或N-钙粘蛋白2)在中枢神经系统神经元中特异性表达，被认为参与神经元发育(8)。