FITC标记的核苷转运蛋白ENT1抗体
产品名称： FITC标记的核苷转运蛋白ENT1抗体
英文名称： Anti-ENT1/FITC
产品编号： HZ-13077R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ENT1/FITC Conjugated antibody
FITC标记的核苷转运蛋白ENT1抗体
| 英文名称 | Anti-ENT1/FITC |
| 中文名称 | FITC标记的核苷转运蛋白ENT1抗体 |
| 别 名 | Equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative nucleoside transporter 1; es-type; MGC1465; MGC3778; Nucleoside transporter; Nucleoside transporter, es-type; OTTHUMP00000016506; OTTHUMP00000016507; OTTHUMP00000016508; OTTHUMP00000016509; OTTHUMP00000016510; OTTHUMP00000016511; OTTHUMP00000016512; S29A1_HUMAN; SLC29A1; solute carrier family 29 (nucleoside transporters), member 1; Solute carrier family 29 member 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, Cynomolgus Monkey, Orangutan |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ENT1/SLC29A1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Equilibrative nucleoside transporters (ENTs) regulate many physiological processes and are widely distributed in mammals, plants, yeasts, insects, nematodes and protozoans. They enable facilitated diffusion of hydrophilic nucleosides, such as adenosine and nucleoside analogs, across cell membranes. ENTs are required for uptake of antiviral and anticancer nucleoside drugs and influence a variety of physiological processes, such as neurotransmission and platelet aggregation, by regulating the amount of adenoside available to cell surface receptors. Equilibrative nucleoside transporter 1 (ENT1), also designated solute carrier family 29 (nucleoside transporters), member 1, belongs to the SLC29A transporter family and is a mammalian ENT isoform. ENT1, along with ENT3, mediates the majority of influx and efflux of nucleosides across the plasma membrane. Function: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). Subcellular Location: Basolateral cell membrane. Apical cell membrane. Predominantly localized in the basolateral membrane in polarised MDCK cells. Tissue Specificity: Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. Post-translational modifications: Glycosylated. Similarity: Belongs to the SLC29A transporter family. Database links: Entrez Gene: 2030 Human Entrez Gene: 63959 Mouse Omim: 602193 Human SwissProt: Q99808 Human SwissProt: Q9JIM1 Mouse Unigene: 25450 Human Unigene: 29744 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
平衡核苷转运体（ENT）调节许多生理过程，广泛分布于哺乳动物、植物、酵母、昆虫、线虫和原生动物中。它们能够促进亲水核苷（如腺苷和核苷类似物）在细胞膜上的扩散。ENT是摄取抗病毒和抗癌核苷药物所必需的，通过调节细胞表面受体可获得的腺苷的量而影响各种生理过程，如神经传递和血小板聚集。平衡核苷转运体1（ENT1），也称为溶质载体家族29（核苷转运体），成员1，属于SLC29A转运体家族，是哺乳动物耳鼻喉科的同型体。EtT1与Et3一起介导核膜在质膜上的大部分流入和流出。