FITC标记的GATA结合蛋白2伴侣蛋白抗体-抗体-抗体-生物在线
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FITC标记的GATA结合蛋白2伴侣蛋白抗体

FITC标记的GATA结合蛋白2伴侣蛋白抗体

商家询价

产品名称： FITC标记的GATA结合蛋白2伴侣蛋白抗体

英文名称： Anti-FOG2/FITC

产品编号： HZ-11942R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-FOG2/FITC Conjugated antibody

FITC标记的GATA结合蛋白2伴侣蛋白抗体

 

英文名称 Anti-FOG2/FITC
中文名称 FITC标记的GATA结合蛋白2伴侣蛋白抗体
别    名 FOG-2; FOG2_HUMAN; Friend of GATA 2; Friend of GATA protein 2; Friend of GATA2 ; hFOG-2 ; ZFPM2; Zinc finger protein 89B; Zinc finger protein M2; Zinc finger protein multitype 2 ; Zinc finger protein ZFPM2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  神经生物学  信号转导  转录调节因子  锌指蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 128kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FOG2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The FOG family of transcriptional cofactors, including FOG (friend of GATA-1) and FOG-2, are zinc finger proteins that interact with the GATA family of transcriptional regulators. FOG/GATA-1 complexes are required for erythroid and megakaryocyte maturation, and they promote differentiation during embryonic development. These complexes involve the association between multiple zinc fingers on the FOG proteins and the N-terminal zinc finger of GATA proteins. While FOG cooperatively regulates GATA-1 induced transcription, FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.

Function:
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.

Subunit:
Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Able to bind GATA1 in vitro. Interacts with NR2F2 and NR2F6

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed at low level.

DISEASE:
Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.

Similarity:
Belongs to the FOG (Friend of GATA) family.
Contains 3 C2H2-type zinc fingers.
Contains 5 C2HC-type zinc fingers.

Database links:

Entrez Gene: 23414 Human

Omim: 603693 Human

SwissProt: Q8WW38 Human

Unigene: 431009 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   
   

转录辅因子的FOG家族，包括FOG（GATA-1的朋友）和FOG-2，是与转录调控因子GATA家族相互作用的锌指蛋白。FOG/GATA-1复合物是红血球和大核细胞成熟所必需的，它们促进胚胎发育过程中的分化。这些复合物涉及FOG蛋白上的多个锌指与GATA蛋白的N-末端锌指之间的关联。当FOG协同调节GATA-1诱导的转录时，FOG-2能够同时对GATA介导的转录产生积极和消极的影响。FOG-2主要表达于心脏、神经元和性腺，并优先参与GATA-3、GATA-4和GATA-6的调节。在心肌细胞和成纤维细胞中，FOG-2抑制GATA-4转录活性，然而在缺乏FOG的红细胞培养物中，FOG-2恢复GATA-1介导的转录，这表明所观察到的FOG-2的作用是上下文特异性的，并且在细胞系统之间有所不同。