FITC标记的γ-衔接蛋白相关蛋白2抗体
产品名称： FITC标记的γ-衔接蛋白相关蛋白2抗体
英文名称： Anti-GGA2/FITC
产品编号： HZ-13344R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GGA2/FITC Conjugated antibody
FITC标记的γ-衔接蛋白相关蛋白2抗体
| 英文名称 | Anti-GGA2/FITC |
| 中文名称 | FITC标记的γ-衔接蛋白相关蛋白2抗体 |
| 别 名 | 1200007E24Rik; ADP ribosylation factor binding protein 2; ADP ribosylation factor binding protein GGA 2; ADP ribosylation factor binding protein GGA2; ADP-ribosylation factor-binding protein GGA2; ARF-binding protein 2; FLJ20966; Gamma adaptin related protein 2; gamma ear-containing; Gamma-adaptin-related protein 2; GGA 2; Gga2; GGA2_HUMAN; Golgi associated gamma adaptin ear containing ARF binding protein 2; Golgi localized gamma ear containing ARF binding protein 2; Golgi-localized; KIAA1080; Vear; VHS domain and ear domain containing protein; VHS domain and ear domain of gamma adaptin; VHS domain and ear domain of gamma-adaptin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GGA2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: A family of proteins, the GGAs (Golgi-localized, g-adaptin ear-containing, ARF-binding proteins) sequences that showed significant homology to the carboxy-terminal 'ear' domain of g-adaptin. Members of the GGA family (GGA1,GGA2 (also known as VEAR or VHS domain and ear domain of g-adaptin) and GGA3) are ubiquitous coat proteins that facilitate the trafficking of proteins between the trans-Golgi network and the lysosome. However, unlike g-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. GGA2 shares 45% amino acid sequence identity with GGA1 and 35% with GGA3. In addition to being involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex, GGA2 may have a tissue-specific function and is highly expressed in kidney, muscle and heart. Furthermore, the VHS domain of GGA2 binds to the acidic cluster-di-leucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR) and this is important for lysosomal enzyme targeting. Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Subunit: Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2. Subcellular Location: Golgi apparatus; trans-Golgi network membrane. Endosome membrane. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Ubiquitinated. Similarity: Belongs to the GGA protein family. Contains 1 GAE domain. Contains 1 GAT domain. Contains 1 VHS domain. Database links: UniProtKB/Swiss-Prot: Q9UJY4.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
一个蛋白家族，GGAs（Golgi-localed，g-adaptin ear-.，ARF结合蛋白）序列，与g-adaptin的羧基末端“ear”结构域具有显著的同源性。GGA家族的成员(GGA1，GGA2(也称为VEAR或VHS结构域和g-adaptin的耳结构域)和GGA3)是普遍存在的外壳蛋白，它们促进蛋白质在跨高尔基体网络和溶酶体之间的运输。然而，与g-适配素不同，GGA不与包膜囊泡或AP-1复合物的任何组分相关。GGA1和GAA2也不是相互关联的，虽然它们共定位在核周膜上。GGA2与GGA1共有45%个氨基酸序列，GGA3共有35%个氨基酸序列。除了参与与高尔基复合物相关的异型囊泡/亚细胞器相互作用外，GGA2可能具有组织特异性功能，并在肾、肌肉和心脏中高度表达。此外，GGA2的VHS结构域与阳离子非依赖性甘露糖6-磷酸受体（CI-MPR）胞质尾部的酸性簇-二亮氨酸基序结合，这对溶酶体酶靶向具有重要意义。