FITC标记的乙醇脱氢酶5抗体
产品名称: FITC标记的乙醇脱氢酶5抗体
英文名称: Anti-ADH5/FITC
产品编号: HZ-12448R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ADH5/FITC Conjugated antibody
FITC标记的乙醇脱氢酶5抗体 |
英文名称 | Anti-ADH5/FITC |
中文名称 | FITC标记的乙醇脱氢酶5抗体 |
别 名 | ADH 3; ADH5; ADHX; ADHX_HUMAN; Alcohol dehydrogenase (class III) chi polypeptide; alcohol dehydrogenase 5 (class III) chi polypeptide; Alcohol dehydrogenase 5; Alcohol dehydrogenase class 3; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class III; Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; class III alcohol dehydrogenase 5 chi subunit; FALDH; FDH; formaldehyde dehydrogenase; Glutathione dependent formaldehyde dehydrogenase; Glutathione-dependent formaldehyde dehydrogenase; GSH-FDH; hydroxymethyllutathione dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 40kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human ADH5 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH5 (alcohol dehydrogenase 5 (class III)), also known as FDH (formaldehyde dehydrogenase), ADHX, ADH-3 or GSNOR, is a 374 amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione, a product formed spontaneously between formaldehyde and glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans. Function: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. Database links: Entrez Gene: 128 Human Entrez Gene: 11532 Mouse Entrez Gene: 100145871 Rat Omim: 103710 Human SwissProt: P11766 Human SwissProt: P28474 Mouse SwissProt: P12711 Rat Unigene: 78989 Human Unigene: 3874 Mouse Unigene: 222115 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
醇脱氢酶家族蛋白质代谢多种底物,包括视黄醇、羟基类固醇、乙醇、脂肪醇和脂质过氧化产物。ADH5(醇脱氢酶5(III类)),又称FDH(甲醛脱氢酶)、ADHX、ADH-3或GSNOR,是一种374个氨基酸的细胞质蛋白,属于醇脱氢酶的III亚家族。ADH5表达普遍,它使用铁作为辅助因子来催化氧化长链伯醇和S-羟甲基谷胱甘肽,一种在甲醛和谷胱甘肽之间自发形成的产物。ADH5作为均聚体存在,并且通过其氧化S-羟甲基谷胱甘肽的能力,从而消除甲醛,作为细胞代谢的重要组成部分发挥作用。编码ADH5基因的遗传变异可能影响人类的药物和酒精依赖。