FITC标记的磷酸化DNA拓普西异构酶Ⅱ抗体
产品名称： FITC标记的磷酸化DNA拓普西异构酶Ⅱ抗体
英文名称： Anti-phospho-Topoisomerase II alpha (Ser1525)/FITC
产品编号： HZ-17592R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-phospho-Topoisomerase II alpha (Ser1525)/FITC Conjugated antibody
FITC标记的磷酸化DNA拓普西异构酶Ⅱ抗体
| 英文名称 | Anti-phospho-Topoisomerase II alpha (Ser1525)/FITC |
| 中文名称 | FITC标记的磷酸化DNA拓普西异构酶Ⅱ抗体 |
| 别 名 | Topoisomerase II alpha (phospho S1525); alpha isozyme; ATP hydrolyzing DNA topoisomerase II alfa; DNA gyrase; DNA topoisomerase 2 alpha; DNA topoisomerase 2-alpha; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA topoisomerase II; DNA Topoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; Topoisomerase DNA II alpha 170kDa; TP2A; Topo IIα; Topo-IIα. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 发育生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 174kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Topoisomerase II alpha around the phosphorylation site of Ser1525 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Subcellular Location: Cytoplasm. Nucleus > nucleoplasm. Generally located in the nucleoplasm. Post-translational modifications: Phosphorylation has no effect on catalytic activity. Similarity: Belongs to the type II topoisomerase family. Database links: Entrez Gene: 7153 Human Entrez Gene: 21973 Mouse Entrez Gene: 360243 Rat Omim: 126430 Human SwissProt: P11388 Human SwissProt: Q01320 Mouse SwissProt: P41516 Rat Unigene: 156346 Human Unigene: 4237 Mouse Unigene: 90996 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
这个基因编码一个DNA拓扑异构酶，一种控制和改变DNA转录过程中的拓扑状态的酶。这种核酶参与诸如染色体凝聚、染色单体分离以及DNA转录和复制过程中产生的扭转应力的缓解等过程。它催化两股双链DNA的瞬时断裂和重新结合，使得两股DNA彼此通过，从而改变DNA的拓扑结构。这种酶的两种形式存在作为基因复制事件的可能产物。编码这种形式的基因α，定位于第17染色体，β基因定位于3号染色体。编码该酶的基因作为多种抗癌药物的靶点，并且该基因的各种突变与耐药性的发展相关。这种酶的活性降低也可能在共济失调毛细血管扩张症中发挥作用。[ RefSeq，JUL 2010 ]