Human Growth Factors & Cytokines
Recombinant Human VEGF-B





 





		Synonyms :
Vascular Endothelial Growth Factor-B, VEGF-related factor, VRF



		Description :
VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine.  It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons.  VEGF-B is expressed in all tissues except the liver.  It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A.  There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186.  Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains.  Both VEGF-B isoforms signal only through the VEGFR1 receptor.  Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.



		Catalog #:
100-20B



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165.  The expected ED50 for this effect is 1.0-2.0 μg/ml.



                AA Sequence :
PVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR 



		PubMed Link :
VEGF-B


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
20μg
$195 
 


 



        Size C
1mg
$3900 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.