TGFβ/ BMP信号通路PCR 芯片(TGFβ/ BMP Signaling Pathway PCR Array)
产品名称： TGFβ/ BMP信号通路PCR 芯片(TGFβ/ BMP Signaling Pathway PCR Array)
英文名称： TGFβ/ BMP Signaling Pathway PCR Array
产品编号： yb243
产品价格： 4800
产品产地： null
品牌商标： null
更新时间： null
使用范围： null
- 联系人 : 谷小姐
- 地址 : 上海市闵行区浦江镇联航路1239弄8B号3楼
- 邮编 : 201112
- 所在区域 : 上海
- 电话 : 181****9791 点击查看
- 传真 : 点击查看
- 邮箱 : gulingzhi@yingbio.com
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TGF. / BMP Signaling Pathway PCR Array TGF. / BMP信号通路PCR 芯片 |
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TGF./BMP信号通路PCR芯片PCR芯片可用于研究TGF./BMP介导的信号转导相关的84个基因的表达，同时测定实验组样本中TGF信号通路活性是被激活，抑制还是没有变化。该芯片涵盖了TGF.超级家族的细胞因子和受体。SMAD和SMAD靶标基因，关联基因包括粘连因子、胞外信号分子以及转录因子都包含其中。一些下游细胞活动和发育过程相关的基因也包含其中。该芯片同时包含了16个通过实验验证得到的显著标志基因，通过分级运算程序可计算得到活性分值。每块芯片上都设定了一组对照通过ΔΔCT方法分别对反转效率，基因组DNA含量和PCR效率进行评估。通过实时定量PCR，使用者通过实时定量PCR，使用者即能够利用该芯片简单可靠地测定TGF信号通路活性并同时检测
TGF./BMP介导的信号转导相关基因的表达。
TGFß Superfamily Ligands:
Activin:INHA, INHBA, INHBB.
BMP:AMH, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, GDF2 (BMP9), GDF3 (VGR-2), GDF5 (CDMP-1), GDF6, GDF7.
Nodal:NODAL.
TGFβ:TGFB1, TGFB2, TGFB3.
Inhibitor/Cofactors:BAMBI, CHRD, DCN, FST, LEFTY1, LTBP1, LTBP2, NOG, TGFBI, TGFBRAP1, THBS1, TGIF1.
TGFß Superfamily Receptors:
Activin:ACVR1 (ALK2), ACVR2A, ACVRL1 (ALK1).
BMP:AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2.
TGFβ:TGFBR1, TGFBR2, TGFBR3.
Transcription Factors and Regulators:DLX2, FOS, GSC, HIPK2, ID1, JUN, JUNB, MYC, RUNX1 (AML1), SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD7, SOX4, STAT1, TGFB1I1, TSC22D1 (TGFB1I4).
SMAD Target Genes:
TGFβ/Activin-Responsive:ATF4, CDKN1A (p21WAF1/p21CIP1), CDKN1B (p27KIP1), CDKN2B (p15INK2B), COL1A1, COL1A2, DCN, EMP1, FOS, GADD45B, GSC, HERPUD1, IFRD1, IGF1, IGFBP3, IL6, JUN, JUNB, MYC, PDGFB, SERPINE1 (PAI-1), TGFB1I1, TNFSF10, TSC22D1 (TGFB1I4), TGFBI, TGIF1.
BMP-Responsive:BGLAP (Osteocalcin), DLX2, ID1, ID2, JUNB, SOX4, STAT1.
Molecules Regulating Signaling of the TGF-ß Superfamily:BAMBI, BMPER, CDKN2B (p15INK2B), CHRD, ENG (Evi-1), MECOM, FST (Follistatin), HIPK2, NOG, PLAU (uPA), RUNX1 (AML1), SMURF1.
Adhesion and Extracellular Molecules:
Adhesion Molecules:BGLAP (Osteocalcin), ENG (Evi-1), TGFB1I1, TGFBI.
Extracellular Matrix Structural Constituents:BGLAP (Osteocalcin), COL1A1, COL1A2, LTBP1, LTBP2, TGFBI.
Genes Involving in Cellular and Developmental Processes:
Apoptosis:CDKN1A (p21WAF1/p21CIP1), CDKN1B (p27KIP1), HIPK2, IGFBP3, INHA, INHBA, STAT1, TGFB1.
Embryonic Development:BMP4, INHBA, MECOM, SMAD3, SMURF1.
Muscle Development:DCN, IGF1, SMAD3.
Neurogenesis:DLX2, INHA, INHBA, NOG.
Reproduction:AMH, AMHR2, FST (Follistatin), INHA, INHBA, INHBB.
Skeletal Development:BGLAP (Osteocalcin), BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR2, CHRD, COL1A1, COL1A2, IGF1, INHA, INHBA, NOG.
Pathway Activity Signature Genes: ACTC1, BMPR2, EGR2, FAS, FGF2, FSTL3, JUNB, KANK4, KLHL24, NOV, PMEPA1, SERPINE1, SMAD6, SOX4, STK38L, UBASH3B.