PCR Array

细胞能动性PCR芯片可用于分析参与细胞运动的84个关键基因的表达。许多细胞依赖细胞运动开展生物过程，如发育、感染和损伤反应。生物刺激如生长因子的释放，会诱导特定的细胞迁移，从而使激活肌动蛋白细胞骨架。

The Human Cell Motility RT² Profiler™ PCR Array profiles the expression of 84 key genes involved in the movement of cells. Many cell types rely on cellular movement for important biological processes such as development, as well as infection and injury response. Stimuli such as growth factor release induce specific cells to migrate, requiring actin cytoskeleton mobilization. The actin cytoskeleton, regulated by the Rho small GTPase family, initially forms cellular projections to mediate either the forward movement of a cell or the development of mature cellular processes (e.g. axons). Cells use adhesion proteins to maintain forward progress, from the rolling migration of a leukocyte along the blood vessel endothelium to the mesenchymal movement of a fibroblast along the extracellular matrix. This array contains growth factors and receptors important for chemotaxis, genes involved in Rho family signaling and adhesion, and genes encoding components of various cellular projections. Using real-time PCR, you can easily and reliably analyze the expression of a focused panel of genes involved in cell motility with this array.

The RT² Profiler PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.

96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available. 
Available for cells, tissues, FFPE samples and small samples

Chemotaxis: FGF2, ITGB2, MAPK1 (ERK2), MYH10, MYH9, PLAUR (uPAR), PLD1, PRKCA, RAC2, TGFB1,
VEGFA, WASF2, WIPF1.

Receptors: EGFR, IGF1R, ITGA4, ITGB1, ITGB2, ITGB3, MET, PLAUR (uPAR), RHO.

Growth Factors: CSF1 (MCSF), EGF, FGF2, HGF, IGF1, TGFB1, VEGFA.

Rho Family GTPases:
Rho Signaling: ACTR2, ACTR3, ARHGDIA, LIMK1, MSN, MYL9, MYLK, PLCG1, PLD1, PRKCA, PTEN, PTPN1,
RHO, RHOA, RHOB, RHOC, RND3, ROCK1, VIM.
Rac Signaling: ACTR2, ACTR3, BAIAP2, CFL1, CRK, PAK1, PAK4, PLD1, PRKCA, RAC1, RAC2, STAT3, WASF1,
WASF2, WASL.
Cdc42 Signaling: ACTR2, ACTR3, CDC42, PFN1, WASF1, WASF2, WASL.

Adhesion:
Cell-Cell Adhesion: DPP4, EGFR, EZR, ITGA4, ITGB1, ITGB2, MSN, MYH9, ROCK1, TGFB1.
Cell-Matrix Adhesion: ACTN1, ACTN3, CSF1 (MCSF), ILK, ITGB1, ITGB2, ITGB3, MMP14, PTEN, PTK2B, PXN, RASA1, 
RHOA.
Focal Adhesion: ACTN1, ACTN3, ARHGEF7, BCAR1, CAPN1, CAPN2, CAV1, ENAH, ILK, ITGB1, MYL9, PTK2,
PTK2B, PXN, TLN1, VASP, VCL.
Leukocyte Adhesion & Rolling: EZR, ITGA4, ITGB1, ITGB2, MSN, ROCK1.

Integrin-Mediated Signaling: BCAR1, ILK, ITGA4, ITGB1, ITGB2, ITGB3, MYH9, PTK2.
Cellular Projections:
Filopodia: BAIAP2, CDC42, DIAPH1, EGFR, ENAH, EZR, MSN, RDX, SVIL, VASP.
Lammelipodia: CTTN, DPP4, EGFR, ENAH, FAP, PIK3CA (p110a), PLD1, PTK2, PXN, RDX, SVIL, VASP, VCL,
WASF1, WASF2, WASL.
Stress Fibers: ACTN4, DIAPH1, MYH10, MYH9, RHOA, RHOB, RHOC.
Membrane Blebs: ACTN1, ACTN3, ACTN4, EZR, MYH10, MYH9, MYLK, RND3, ROCK1.
Invasive Projections: ACTR2, ACTR3, ARF6, CDC42, CFL1, CTTN, DPP4, EGF, EZR, FAP, MMP14, MMP2
(Gelatinase A), MMP9 (Gelatinase B), MSN, MYH9, PLAUR (uPAR), RAC2, RASA1, SH3PXD2A, SRC, SVIL, TGFB1,
VEGFA, WASL, WIPF1.
Growth Cones: ARHGEF7, CDC42, CFL1, PTK2B.
Membrane Ruffles: ACTR2, ACTR3, ARF6, BAIAP2, BCAR1, CTTN, DIAPH1, EZR, ITGB1, MYH9, RAC1, RAC2,
RDX, RHOA, TLN1, WASF2.

Cell Polarity: CDC42, CFL1, EZR, IGF1R, ILK, MYH9.

Proteolysis: AKT1, CAPN1, CAPN2, DPP4, FAP, HGF, MMP14, MMP2 (Gelatinase A), MMP9 (Gelatinase B),
MYH9, PLAUR (uPAR), TIMP2.