Product: Anti-CCR8, Polyclonal
Cat. No: PC-049 (100 μg)
Background:
CCR8 is one of the chemokine receptors that
are required as coreceptors for HIV infection.
The genes encoding human and murine CCR8
were cloned and designated TER1, CKR-L1,
and ChemR1 (1-4). The encoded seven
transmembrane protein was identified as the
receptor for human CC chemokine I-309 and
renamed CCR8. Recently, CCR8 was found to
serve as a coreceptor for diverse T-cell tropic,
dual-tropic and macrophage-tropic HIV-1 strains
(5). CCR8 mediates CC chemokine I-309
induced monocyte chemoattraction and HIV-1
envelope fusion and virus infection, which can
be prevented by the CCR8 ligand I-309. CCR8
is expressed in spleen, thymus and T
lymphoblastic cell lines.
Specificity:
This antibody recognizes CCR8.
Positive control: Human spleen tissue lysate. An
approximately 50 kDa band can be detected.
Species Reactivity:
Human, other species not tested.
Ig Isotype: Rabbit IgG
Immunogen:
A peptide corresponding to amino acids 183 to
201 of human CCR8, which locate in the second
extracellular loop.
Format:
Affinity chromatography purified IgG, 100 μg in
200 μl of PBS containing 0.02% sodium azide.
Storage and Stability:
Stable for at least one year when stored at 4°C.
Applications and Suggested Dilutions:

Western blot: Suggested dilution: 1:500 to
1:1000.
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product