Claudin 17,紧密连接蛋白17抗体

产品编号HZ-13751R
英文名称Claudin 17
中文名称紧密连接蛋白17抗体
别 名CLDN17; CLD17_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 跨膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Horse,
Claudin 17,紧密连接蛋白17抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Claudin 17
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Claudin 17,紧密连接蛋白17抗体PubMedPubMed
产品介绍background:
The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules (JAMs). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Mammalian claudin-17 and claudin-8 may be the result of a gene duplication. Claudin-17 is expressed in stratum granulosum of the epidermis and infundibulum and predominantly localizes to the plasma membrane.

Function:
Claudin proteins are a family of transmembrane proteins associated with tight junctions, and different tissues exhibit different Claudin composition. There are 18 homolgs present in humans, and mutations in any of these proteins cause a variety of human disease, this indicates their physiological importance. CLDN17, clustered with CLDN8 at human chromosome 21q22.11, is a four transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.

Subcellular Location:
Integral membrane protein. Tight junctions.

Similarity:
Belongs to the claudin family.

Gene ID:
26285

Claudin 17,紧密连接蛋白17抗体Database links:
Entrez Gene: 26285 Human
Entrez Gene: 239931 Mouse
Omim: 609131 Human
SwissProt: P56750 Human
SwissProt: Q8BXA6 Mouse
Unigene: 258589 Human
Unigene: 126860 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.