Contactin 4 + 6,轴突相关粘附分子抗体

产品编号HZ-11636R
英文名称Contactin 4 + 6
中文名称轴突相关粘附分子抗体
别 名Contactin 4+6; Contactin 4 + Contactin 6; Contactin 4 / Contactin 6; AXCAM; axonal-associated cell adhesion molecule; BIG 2; BIG2; Brain-derived immunoglobulin superfamily protein 2; CNTN4; CNTN4A; CNTN4_HUMAN; CNTN6; CNTN6_HUMAN; Contactin 4; Contactin4; Contactin-4; Contactin-6; Contactin6; Contactin 6; hNB-3; NB3; neural cell adhesion protein BIG-2; Neural recognition molecule NB-3.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 神经生物学 细胞粘附分子 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Sheep,
Contactin 4 + 6,轴突相关粘附分子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量114kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Contactin 4 + 6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Contactin 4 + 6,轴突相关粘附分子抗体PubMedPubMed
产品介绍background:
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Tissue specificity: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Similarity: Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Function:
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor

Tissue Specificity:
Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.

Similarity:
Belongs to the immunoglobulin superfamily. Contactin family.
Contains 4 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Contactin 4 + 6,轴突相关粘附分子抗体Database links:
Entrez Gene: 152330 Human
Entrez Gene: 27255 Human
Entrez Gene: 269784 Mouse
Entrez Gene: 116658 Rat
SwissProt: Q8IWV2 Human
SwissProt: Q69Z26 Mouse
SwissProt: 62845 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.