FITC标记的法尼基二磷酸法尼基转移酶1/鲨烯合成酶抗体
产品名称： FITC标记的法尼基二磷酸法尼基转移酶1/鲨烯合成酶抗体
英文名称： Anti-FDFT1/FITC
产品编号： HZ-11517R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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Rabbit Anti-FDFT1/FITC Conjugated antibody
FITC标记的法尼基二磷酸法尼基转移酶1/鲨烯合成酶抗体
| 产品编号 | bs-11517R-FITC |
| 英文名称 | Anti-FDFT1/FITC |
| 中文名称 | FITC标记的法尼基二磷酸法尼基转移酶1/鲨烯合成酶抗体 |
| 别 名 | DGPT; ERG9; Farnesyl diphosphate farnesyltransferase 1; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; Presqualene di diphosphate synthase; SQS; Squalene synthase; Squalene synthetase; SS. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FDFT1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Several proteins mediate the biosynthesis of cholesterol. The first specific step in the cholesterol biosynthetic pathway is the conversion of transfarnesyl-diphosphate to Squalene, which is catalyzed by the endoplasmic reticulum membrane-associated enzyme Squalene synthetase, also designated Squalene synthase and Farnesyl-diphosphate farnesyltransferase. Squalene synthetase is located at a branch point in the mevalonate pathway and is also involved in isoprenoid biosynthesis. Squalene epoxidase, also designated Squalene monooxygenase, is a multi-pass microsomal membrane-associated enzyme that catalyzes the first oxygenation step in sterol biosynthesis and most likely functions as one of the rate-limiting enzymes in this pathway. Squalene epoxidase may form a complex with Squalene synthetase. Function: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. Subunit: Monomer Subcellular Location: Endoplasmic reticulum membrane. Similarity: Belongs to the phytoene/squalene synthase family. Database links: Entrez Gene: 2222 Human Entrez Gene: 14137 Mouse Omim: 184420 Human SwissProt: P37268 Human SwissProt: P53798 Mouse Unigene: 593928 Human Unigene: 474432 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
几种蛋白质介导胆固醇的生物合成。胆固醇生物合成途径中的第一个具体步骤是将转法尼基二磷酸转化为角鲨烯，其由内质网膜相关酶角鲨烯合成酶催化，也被命名为角鲨烯合酶和Farnesyl diphosphate farnesyltransferase。鲨烯合成酶位于甲羟戊酸途径中的一个分支点，也参与异戊二烯生物合成。角鲨烯环氧化酶，也被命名为鲨烯单加氧酶，是多道微粒体膜相关酶，催化甾醇生物合成中的第一氧合步骤，并且最有可能作为该途径中的限速酶之一。角鲨烯环氧酶可能与角鲨烯合成酶形成络合物。