FITC标记的钙粘蛋白14抗体
产品名称： FITC标记的钙粘蛋白14抗体
英文名称： Anti-CDHF14/FITC
产品编号： HZ-13721R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CDHF14/FITC Conjugated antibody
FITC标记的钙粘蛋白14抗体
| 英文名称 | Anti-CDHF14/FITC |
| 中文名称 | FITC标记的钙粘蛋白14抗体 |
| 别 名 | Cadherin family member 14; CDHF14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT4; FAT4_HUMAN; FATJ; hFat4; Nbla00548; Protocadherin Fat 4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞粘附分子 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 538kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDHF14 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell to cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT4 (FAT tumor suppressor homolog 4), also known as FAT-J, CDHF14 or CDHR11, is a 4,981 amino acid single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins and localizes to the primary cilia of kidney. Widely expressed, FAT4 contains thirty-four cadherin domains, six EGF-like domains and two laminin G-like domains. FAT4 may function in the regulation of planar cell polarity. Function: May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules. Subcellular Location: Membrane. In the kidney, localizes to primary cilia. Tissue Specificity: Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. Similarity: Contains 34 cadherin domains. Contains 6 EGF-like domains. Contains 2 laminin G-like domains. Database links: Entrez Gene: 79633 Human SwissProt: Q6V0I7 Human Unigene: 563205 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
钙粘附素是一类钙依赖性粘附分子，其功能是介导细胞与细胞的结合，这对维持结构和形态发生至关重要。Cadherins在N端包含一个大的细胞外结构域，其特征是一系列五个同源重复，其中最远端被认为负责结合特异性。相对短的C端胞内结构域与各种细胞质蛋白相互作用，包括β-连环蛋白，以调节钙粘蛋白的功能。钙粘蛋白超家族包括钙黏附素、原粘蛋白、桥粒芯糖蛋白和桥粒蛋白。FAT4(FAT肿瘤抑制物同源物4)又称FAT-J、CDHF14或CDHR11，是一种4981个氨基酸的单程I型膜蛋白，属于钙粘蛋白的原钙粘蛋白亚家族，定位于肾的初级纤毛。广泛表达的FAT4含有三十四个钙粘蛋白结构域，六个EGF样结构域和两个层粘连蛋白G样结构域。FAT4可能在平面细胞极性的调节中起作用。