FITC标记的ELAVL2+ELAVL4蛋白抗体
产品名称： FITC标记的ELAVL2+ELAVL4蛋白抗体
英文名称： Anti-ELAVL2 + ELAVL4/FITC
产品编号： HZ-11743R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ELAVL2 + ELAVL4/FITC Conjugated antibody
FITC标记的ELAVL2+ELAVL4蛋白抗体
| 产品编号 | bs-11743R-FITC |
| 英文名称 | Anti-ELAVL2 + ELAVL4/FITC |
| 中文名称 | FITC标记的ELAVL2+ELAVL4蛋白抗体 |
| 别 名 | ELAV like 4; ELAV like neuronal protein 1; ELAV like protein 2; ELAV like protein 4; ELAVL 2; ELAVL 4; HELN1; Hu antigen B; Hu antigen D; HUB; HUD; ELAV2_HUMAN; ELAV4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39+42kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ELAVL2 (31-110aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites. Function: ELAV2 binds RNA and seems to recognize a GAAA motif and is neuronal specific. ELAVL4 may play a role in neuron-specific RNA processing. It contains 3 RNA recognition motif (RRM) domains and is localised to brain tissue. ELAVL4 has been linked with the disease, paraneoplastic encephalomyelitis sensory neuropathy, which is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities. This disease may result from an immune response primarily directed against a small cell lung tumor antigen which is misdirected against similar antigens expressed in brain (such as ELAVL4). Subcellular Location: Interacts with IGF2BP1. Tissue Specificity: Brain; neural-specific. Similarity: Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains. Database links: UniProtKB/Swiss-Prot: Q12926.2 UniProtKB/Swiss-Prot: P26378.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ELAV样基因编码一系列RNA结合蛋白。果蝇蛋白Elav和第一个描述的成员，在神经母细胞分化为神经元后立即表达，对于神经元分化和维持是必需的。一些哺乳动物ELAV样蛋白，指定HUC，HUD和Hel-N1，也表达在有丝分裂后神经元。另一种哺乳动物同源物，HUR，也被指定为华，广泛表达，并在多种肿瘤中也过表达。典型地，这些同源物都包含三个RNA识别基序（RRM），并且它们在mRNA转录物的3’-非翻译区中与富含Au的元素（WAS）特异性结合。位点靶向mRNA的快速降解，从而调节参与细胞生长和分化的基因的表达水平。当ELAV样蛋白与这些位点相关时，该降解被抑制，导致相应转录物的稳定性增加。ELAV蛋白在细胞核内起作用，它们通过核输出信号在细胞核和细胞质之间穿梭，这是ELAV样蛋白的调节特征，因为它限制了它们对位点的可访问性。