FITC标记的环腺苷酸应答元件结合蛋白样蛋白2抗体
产品名称： FITC标记的环腺苷酸应答元件结合蛋白样蛋白2抗体
英文名称： Anti-CREBL2/FITC
产品编号： HZ-14054R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CREBL2/FITC Conjugated antibody
FITC标记的环腺苷酸应答元件结合蛋白样蛋白2抗体
| 英文名称 | Anti-CREBL2/FITC |
| 中文名称 | FITC标记的环腺苷酸应答元件结合蛋白样蛋白2抗体 |
| 别 名 | cAMP responsive element binding protein like 2; CREBL 2; MGC117311; MGC138362; MHBs-binding protein 1; CRBL2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 染色质和核信号 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CREBL2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008] Function: CREBL2 is frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. Subunit: Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Subcellular Location: Nuclear Post-translational modifications: Phosphorylated by AMPK. Similarity: Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain. Database links: Entrez Gene: 1389 Human Entrez Gene: 537195 Cow Entrez Gene: 232430 Mouse Entrez Gene: 362453 Rat Entrez Gene: 100038265 Xenopus tropicalis Omim: 603476 Human SwissProt: Q0VD32 Cow SwissProt: O60519 Human SwissProt: Q32M00 Mouse SwissProt: Q5BJU6 Rat SwissProt: A4IGK3 Xenopus tropicalis Unigene: 591156 Human Unigene: 267010 Mouse Unigene: 107553 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
cAMP应答元件(CRE)-结合蛋白样蛋白-2(CREBL2)在寻找12p13染色体上通常缺失的ETV6和CDKN1B基因两侧的基因时被鉴定，这些基因通常与造血系统恶性肿瘤以及乳腺癌、非小细胞肺癌和卵巢癌相关。CYBL2与CRE结合蛋白（CREB）在48碱基长区域中具有41%的同源性，编码编码BCRIP结构域的CREB。bZip结构域包含大约30个氨基酸，富含参与DNA结合的碱性残基，接着是参与蛋白质二聚的亮氨酸拉链基序。这表明CYBL2编码具有DNA结合能力的蛋白质。CCRB2在恶性肿瘤中的缺失提示CCRB2可能作为肿瘤抑制基因。[ RefSeq，JUL 2008 ]