肿瘤抑制miRNA PCR芯片(Tumor Suppressor miRNAs miScript miRNA PCR Array )
产品名称: 肿瘤抑制miRNA PCR芯片(Tumor Suppressor miRNAs miScript miRNA PCR Array )
英文名称: Tumor Suppressor miRNAs miScript miRNA PCR Array
产品编号: yb261
产品价格: 4800
产品产地: null
品牌商标: null
更新时间: null
使用范围: null
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- 邮编 : 201112
- 所在区域 : 上海
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miScript miRNA PCR Array |
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肿瘤抑制miRNA PCR芯片用于研究被确认为肿瘤抑制miRNA 的84 个miRNA的表达。癌基因可以激活致癌过程,如细胞周期进展、入侵和转移。这些基因通常通过信号通路起作用,如RAS及表观遗传调控。肿瘤抑制基因(TSGs) 通过抑制这些致癌过程阻碍致癌基因, 它们在肿瘤中表达往往是表达下调。因此,抑制肿瘤发生或以致癌基因为靶标的miRNA被认为是肿瘤抑制miRNA。根据癌症类型研究,一些TSGs也可以作为致癌基因。这个芯片为癌症研究人员提供了一个方便快速的方法来分析与各种各样的癌症最相关的肿瘤抑制miRNA。剖析这些miRNA在肿瘤样本的表达,可促进研究miRNA与生物表型或分期、治疗选择、转移、复发和生存率等临床结果之间的关系。每张芯片含一个对照组使得分析数据时可以用相对定量ΔΔCT方法评估逆转录效率,基因组DNA污染,和PCR效率。利用这张芯片,通过实时定量PCR,可以简易且可靠地检测与肿瘤抑制相关的miRNA的表达。
miRNAs that Regulate Common Oncogene Classes:
Apoptosis:let-7a-5p, miR-122-5p, miR-125b-5p, miR-141-3p, miR-143-3p, miR-15a-5p, miR-16-5p, miR-181a-5p, miR-181b-5p, miR-192-5p, miR-195-5p, miR-200b-3p, miR-200c-3p, miR-211-5p, miR-215-5p, miR-22-3p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-30a-5p, miR-30c-5p, miR-34a-5p, miR-34c-5p, miR-424-5p, miR-497-5p, miR-7-5p.
Epigenetic Regulation:miR-101-3p, miR-124-3p, miR-126-3p, miR-137, miR-138-5p, miR-140-5p, miR-143-3p, miR-152-3p, miR-185-5p, miR-214-3p, miR-25-3p, miR-26a-5p, miR-26b-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-372-3p, miR-517a-3p, miR-520c-3p.
Transcriptional Regulation:miR-124-3p, miR-128-3p, miR-145-5p, miR-185-5p, miR-200a-3p, miR-214-3p, miR-25-3p, miR-502-5p.
Immune Regulation:let-7d-5p, let-7e-5p, let-7f-5p, miR-155-5p, miR-98-5p.
Tyrosine Kinases:let-7a-5p, let-7b-5p, miR-1, miR-100-5p, miR-125a-5p, miR-125b-5p, miR-128-3p, miR-133a-3p, miR-133b, miR-137, miR-140-5p, miR-146a-5p, miR-150-5p, miR-193a-3p, miR-193b-3p, miR-196b-5p, miR-206, miR-218-5p, miR-223-3p, miR-23b-3p, miR-24-3p, miR-29a-3p, miR-34a-5p, miR-34b-3p, miR-34c-5p, miR-449a, miR-542-5p, miR-7-5p, miR-99a-5p.
G-protein Signaling:let-7a-5p, let-7b-5p, let-7c-5p, let-7g-5p, let-7i-5p, miR-126-3p, miR-142-3p, miR-143-3p, miR-145-5p, miR-155-5p, miR-193a-3p, miR-193b-3p, miR-196b-5p, miR-216b-5p, miR-622, miR-96-5p.
Other Oncogenes:miR-1291, miR-370-3p.
miRNAs also Considered Oncogenes:miR-122-5p, miR-125b-5p, miR-146a-5p, miR-155-5p, miR-181a-5p, miR-211-5p, miR-29a-3p, miR-29b-3p, miR-29c-3p, miR-34a-5p.
Other miRNAs:miR-296-5p, miR-335-5p, miR-483-3p, miR-483-5p, miR-486-5p.