NEK1,丝氨酸/苏氨酸蛋白激酶NEK1抗体'

产品编号HZ-7814R
英文名称NEK1
中文名称丝氨酸/苏氨酸蛋白激酶NEK1抗体
别 名NEK1; NEK1_HUMAN; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; Renal carcinoma antigen NY-REN-55; Serine/threonine-protein kinase Nek1; SRPS2; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
NEK1,丝氨酸/苏氨酸蛋白激酶NEK1抗体'产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量143kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NEK1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NEK1,丝氨酸/苏氨酸蛋白激酶NEK1抗体'PubMedPubMed
产品介绍background:
The protein encoded by this gene is a serine/threoninekinase involved in cell cycle regulation. The encoded protein isfound in a centrosomal complex with FEZ1, a neuronal protein thatplays a role in axonal development. Defects in this gene are acause of polycystic kidney disease (PKD). Several transcriptvariants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2010].

Function:
Phosphorylates serines and threonines, but also appearsto possess tyrosine kinase activity. Implicated in the control ofmeiosis (By similarity). Involved in cilium assembly.

Subunit:
Binds to SPERT (By similarity).

Subcellular Location:
Nucleus (Probable). Cytoplasm, cytoskeleton,centrosome (By similarity). Note=Associated with the pericentriolarmaterial. Localizes to centrosome during interphase and mitosis (Bysimilarity).

NEK1,丝氨酸/苏氨酸蛋白激酶NEK1抗体'Tissue Specificity:
High fetal expression in the brain and kidney.

DISEASE:
Defects in NEK1 are the cause of short rib-polydactylysyndrome type 2 (SRPS2) [MIM:263520]. A lethal skeletal dysplasiacharacterized by markedly short ribs, short limbs, polydactyly, andmultiple anomalies including a narrow thorax with hypoplasticlungs, extreme polysyndactyly, dysproportionate dwarfism, mediancleft lip and palate, a ventriculoseptal defect and cystic kidneys.The radiographic hallmarks include shortened and horizontal ribs,squared scapulae and elevated clavicles with lateral kinking,normal spine and pelvis configuration, and shortening of the bonesof all four extremities, with extreme reduction of tibial bonelength.

Similarity:
Belongs to the protein kinase superfamily. NEK Ser/Thrprotein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.

Database links:
UniProtKB/Swiss-Prot: Q96PY6.2

NEK1,丝氨酸/苏氨酸蛋白激酶NEK1抗体'Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.