FITC标记的离子钙接头蛋白抗体
产品名称： FITC标记的离子钙接头蛋白抗体
英文名称： Anti-AIF1/Iba1/FITC
产品编号： HZ-1363R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-AIF1/Iba1/FITC Conjugated antibody
FITC标记的离子钙接头蛋白抗体
| 英文名称 | Anti-AIF1/Iba1/FITC |
| 中文名称 | FITC标记的离子钙接头蛋白抗体 |
| 别 名 | AIF 1; AIF1; AIF1 protein; IBa1; iba-1; IBa 1; allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; IBA 1; IBA1; interferon gamma responsive transcript; Ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein G1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Iba1 (114-147aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Allograft Inflammatory Factor-1 (AIF1)or ionized calcium-binding adaptor molecule 1 (Iba1) is expressed selectively in microglia/macrophages and is a Ca2+-binding peptide produced by activated monocytes and microglial cells. It has been suggested that AIF1 expression is associated with chronic inflammatory processes. AIF1 is expressed by activated monocytes and might participate in a variety of pathogenic processes in the mammalian brain and in chronic transplant rejection. It has been shown to be expressed early and persistently in chronically rejecting cardiac allografts but not in cardiac syngrafts and host hearts. Function: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. Subunit: Homodimer (Potential). Monomer. Interacts with LCP1. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. Tissue Specificity: Detected in T-lymphocytes and peripheral blood mononuclear cells. Similarity: Contains 2 EF-hand domains. Database links: Entrez Gene: 199 Human Entrez Gene: 11629 Mouse Entrez Gene: 29427 Rat Omim: 601833 Human SwissProt: P55008 Human SwissProt: O70200 Mouse SwissProt: P55009 Rat Unigene: 76364 Human Unigene: 10747 Mouse Unigene: 32080 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 离子钙接头蛋白主要在小胶质细胞表达 |
同种异体移植物炎性因子-1(AIF1)或电离钙结合适配子分子-1(Iba1)选择性地在小胶质细胞/巨噬细胞中表达，是由活化的单核细胞和小胶质细胞产生的钙结合肽。有人认为AIF1表达与慢性炎症过程有关。AIF1由活化的单核细胞表达，可能参与哺乳动物大脑和慢性移植排斥反应的各种致病过程。它已被证明在慢性排斥心脏移植物中早期和持续表达，但在心脏同种异体移植物和宿主心脏中没有表达。