FITC标记的神经突触粘附样分子1抗体
产品名称： FITC标记的神经突触粘附样分子1抗体
英文名称： Anti-LRFN1/FITC
产品编号： HZ-12141R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-LRFN1/FITC Conjugated antibody
FITC标记的神经突触粘附样分子1抗体
| 英文名称 | Anti-LRFN1/FITC |
| 中文名称 | FITC标记的神经突触粘附样分子1抗体 |
| 别 名 | Leucine rich repeat and fibronectin type III domain containing 1; Leucine rich repeat and fibronectin type III domain containing protein 1; Leucine-rich repeat and fibronectin type III domain-containing protein 1; LRFN 1; lrfn1; LRFN1_HUMAN; SALM 2; SALM2; Synaptic adhesion like molecule 2; Synaptic adhesion-like molecule 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRFN1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: LRFN1 is a 771 amino acid single-pass type I membrane protein that belongs to the LRFN family. Containing a fibronectin type-III domain, an Ig-like (immunoglobulin-like) domain, a LRRCT domain, a LRRNT domain and seven LRR (leucine-rich) repeats, LRFN1 is thought to promote neurite outgrowth in hippocampal neurons and is involved in the regulation and maintenance of excitatory synapses. LRFN1 forms heteromeric complexes with LRFN2, LRFN3, LFRN4 and LFRN5, but does not have the ability to form homomeric complexes across cell junctions of adjacent cells like other LRFN family members. The PDZ-binding motif of LRFN1 is required for neurite outgrowth promotion and for SAP 97-, NE-dlg- and PSD-95-binding. LRFN1 is encoded by a gene located on human chromosome 19q13.2 and mouse chromosome 7 A3. Function: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. Subunit: Can form heteromeric complexes with LRFN2, LRFN3, LRFN4 and LRFN5 (By similarity). Forms homomeric complexes, but not across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4. Interacts with 2 AMPA receptor subunits GRIA1 and GRIA2 and NMDA receptor subunit GRIN1 (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane (By similarity). Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Glycosylated. Similarity: Belongs to the LRFN family. Contains 1 fibronectin type-III domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 7 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 57622 Human Entrez Gene: 80749 Mouse Entrez Gene: 365222 Rat Omim: 612807 Human SwissProt: Q9P244 Human SwissProt: Q2WF71 Mouse SwissProt: P0C7J6 Rat Unigene: 97860 Human Unigene: 483073 Mouse Unigene: 234182 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LFRN1是属于LRFN家族的771氨基酸单程I型膜蛋白。LRFN1包含纤维连接蛋白III型结构域、Ig-样(免疫球蛋白-样)结构域、LRRCT结构域、LRRNT结构域和7个LRR(富含亮氨酸)重复序列，被认为促进海马神经元中神经突起的生长，并参与兴奋性突触的调节和维持。LRFN1与LRFN2、LRFN3、LFRN4和LFRN5形成异质配合物，但不能像其他LRFN家族成员那样在邻近细胞的细胞连接处形成同源配合物。LFN1的PDZ结合基序需要用于轴突生长促进和SAP 97、NE-DLG-和PSD-95结合。LFN1由位于人类染色体19q132和小鼠染色体7 A3上的基因编码。