FITC标记的快速发育生长因子同源蛋白2抗体
产品名称： FITC标记的快速发育生长因子同源蛋白2抗体
英文名称： Anti-Sprouty 2/FITC
产品编号： HZ-7507R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Sprouty 2/FITC Conjugated antibody
FITC标记的快速发育生长因子同源蛋白2抗体
| 英文名称 | Anti-Sprouty 2/FITC |
| 中文名称 | FITC标记的快速发育生长因子同源蛋白2抗体 |
| 别 名 | hSPRY 2; hSPRY2; MGC23039; Sprouty homolog 2 (Drosophila); Sprouty homolog 2; Sprouty2; Spry 2; Spry2; SPY2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 干细胞 生长因子和激素 血管内皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Sprouty 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Sprouty was originally identified as an inhibitor of Drosophila epidermal growth factor (EGF) and fibroblast growth factor (FGF) receptor signaling during tracheal development. Four isoforms of mammalian sprouty are known (Spry1-Spry4). The role of the mammalian analogs has not been clearly elucidated although it is believed that human Sprouty 2 (hSpry2) may be an inhibitor of cellular migration and proliferation. Spry2 and Spry4 show considerable sequence homology between human and mouse at the C terminus of the protein. Significant sequence divergence occurs at the N terminus. Spry2 appears to be abundant in brain, lung and heart tissue, with lesser amounts found in kidney and skeletal muscle. Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Subunit: Interacts with RAF1. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). Similarity: Belongs to the sprouty family. Contains 1 SPR (sprouty) domain. Database links: Entrez Gene: 10253 Human Entrez Gene: 24064 Mouse Entrez Gene: 306141 Rat Omim: 602466 Human SwissProt: O43597 Human SwissProt: Q9QXV8 Mouse Unigene: 18676 Human Unigene: 89982 Mouse Unigene: 103294 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Sprouty2是一类在全身组织广泛表达的软脂酰化磷蛋白,在机体的信号转导,尤其是受体蛋白对受体酪氨酸激酶(RTK)等信号通路起着重要的抑制作用,其表达在多种肿瘤组织中发生明显下降,并可进一步引起细胞异常增殖、转化及新生血管形成,从而促进肿瘤的发生及发展 |
Sprouty最初被认为是果蝇表皮生长因子（EGF）和成纤维细胞生长因子（FGF）受体信号在气管发育过程中的抑制剂。已知哺乳动物Spouy4的四种亚型（SRYY1-SPRY4）。哺乳动物类似物的作用还没有被清楚地阐明，尽管人们认为人类Spulouy 2（HSPRY2）可能是细胞迁移和增殖的抑制剂。SpRY2和SpRY4在人的C端具有明显的序列同源性。在N端出现明显的序列差异。SpRY2在脑、肺和心脏组织中含量丰富，在肾脏和骨骼肌中的含量较低。