FITC标记的热休克蛋白J2抗体
产品名称： FITC标记的热休克蛋白J2抗体
英文名称： Anti-DNAJB6/FITC
产品编号： HZ-4949R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DNAJB6/FITC Conjugated antibody
FITC标记的热休克蛋白J2抗体
| 英文名称 | Anti-DNAJB6/FITC |
| 中文名称 | FITC标记的热休克蛋白J2抗体 |
| 别 名 | DJ4; DnaJ; DNAJ B6; DnaJ homolog subfamily B member 6; DNAJB6; DNJB6_HUMAN; Heat shock protein J2; HHDJ1; HSJ-2; HSJ2; MRJ; MSJ-1; MSJ1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 细胞凋亡 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSJ2/DNAJB6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Reduces huntingtin aggregation associated with HD. Also reduces cellular toxicity and caspase-3 activity. Subcellular Location: Cytoplasm > perinuclear region. Nucleus. Tissue Specificity: Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. Similarity: Contains 1 J domain. Database links: Entrez Gene: 282215 Cow Entrez Gene: 10049 Human Entrez Gene: 23950 Mouse Entrez Gene: 362293 Rat Omim: 611332 Human SwissProt: Q0III6 Cow SwissProt: O75190 Human SwissProt: O54946 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在KRT8/KRT18丝的组织中起着不可缺少的作用。作为神经元蛋白的内源性分子伴侣，包括亨廷顿蛋白。对HSP70的ATP酶活性有剂量依赖性和时间依赖性的刺激作用，并因此作为HSP70的共同伴侣。减少与HD相关的亨廷顿聚集。还可降低细胞毒性和caspase-3活性。