FITC标记的突触泡蛋白2B抗体
产品名称： FITC标记的突触泡蛋白2B抗体
英文名称： Anti-SV2B/FITC
产品编号： HZ-11365R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SV2B/FITC Conjugated antibody
FITC标记的突触泡蛋白2B抗体
| 产品编号 | bs-11365R-FITC |
| 英文名称 | Anti-SV2B/FITC |
| 中文名称 | FITC标记的突触泡蛋白2B抗体 |
| 别 名 | Synaptic vesicle protein 2B; SV2B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 77kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SV2B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation. Function: SV2s (Synaptic Vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. While SV2A is expressed ubiquitously throughout the brain, SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. Subunit: Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity). Subcellular Location: Cytoplasmic vesicle, secretory vesicle. Synaptic vesicle membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated (By similarity). The N-terminal cytoplasmic domain is phosphorylated by CK1 (By similarity). Similarity: Belongs to the major facilitator superfamily. Database links: Entrez Gene: 9899 Human Omim: 185861 Human SwissProt: Q6IAR8 Human SwissProt: Q7L1I2 Human Unigene: 592018 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在所有脊椎动物中，Sv2蛋白是丰富的，疏水的，膜糖蛋白，被表达为两种主要的亚型，即Sv2a和Sv2b，以及一种次要的亚型，Sv2c。Sv2蛋白在大脑中差异表达，并且存在于所有的突触小泡上，与传输器类型无关。Sv2a在皮层下大量表达，特别是在突触前神经末梢的突触小泡中，也在大多数神经内分泌分泌颗粒中大量表达。Sv2b显示一种更受限的表达模式，因为它只存在于海马和皮质的突触的小子集上。Sv2a和Sv2b是多余的，是维持脊椎动物正常脑功能所必需的。Sv2a和Sv2b通过调节神经末梢中的胞质Ca2+水平在重复刺激期间介导突触传递。