乳腺癌miRNA PCR芯片(Breast Cancer miScript miRNA PCR Array)
产品名称: 乳腺癌miRNA PCR芯片(Breast Cancer miScript miRNA PCR Array)
英文名称: Breast Cancer miScript miRNA PCR Array
产品编号: yb029
产品价格: 4800
产品产地: null
品牌商标: null
更新时间: null
使用范围: null
- 联系人 : 谷小姐
- 地址 : 上海市闵行区浦江镇联航路1239弄8B号3楼
- 邮编 : 201112
- 所在区域 : 上海
- 电话 : 181****9791 点击查看
- 传真 : 点击查看
- 邮箱 : gulingzhi@yingbio.com
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人乳腺癌miRNAPCR芯片用于分析乳腺癌发生或发展过程中已知或预测发生表达变异的84 个miRNA的表达。这个芯片为癌症研究人员提供了一个方便的方法来快速分析乳腺肿瘤发生最相关的miRNA。乳腺癌是一种异质性疾病,包括多个种类。并不是所有的乳腺肿瘤都表达雌激素受体,需要通过选择性雌激素受体调节剂(SERMs)治疗。此外,一些乳腺癌的进程在化疗治疗中对某些药物产生耐药性。致癌机制的研究经确定了特异表达的基因,由于体细胞突变发生功能缺陷,或由于表观遗传变异基因表达改变。miRNA在表观遗传学上调节mRNA,因此miRNA的失调会影响靶mRNA的表达。miRNA表达芯片分析已被发现的乳腺癌肿瘤形成的潜在生物标记和跟进功能研究的许多结果中的miRNA。这个芯片包括雌激素受体-应答中特异表达或对乳腺肿瘤耐药的miRNA。包括功能已知以及通过miRNA芯片研究或已知乳腺癌生物调节剂推测涉及乳腺癌的miRNA。分析结果将助于了解乳腺癌病理背后的分子机制。每张芯片含一个对照组使得分析数据时可以用相对定量ΔΔCT方法评估逆转录效率,基因组DNA污染,和PCR效率。利用这张芯片,通过实时定量PCR,可以简易且可靠地分析乳腺癌关键miRNA的表达。
miScript miRNA PCR芯片仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。
Potential Biomarkers:
Upregulated:miR-128, miR-210.
Regulated:miR-7-5p.
Drug Resistance:
Upregulated:miR-10a-5p, miR-125b-5p, miR-132-3p, miR-155-5p, miR-186-5p, miR-199a-3p // miR-199b-3p, miR-21-5p, miR-210, miR-212-3p, miR-22-3p, miR-222-3p, miR-29a-3p, miR-31-5p, miR-328.
Downregulated:miR-141-3p, miR-148a-3p, miR-152, miR-15a-5p, miR-15b-5p, miR-181d, miR-193b-3p, miR-200c-3p, miR-205-5p, miR-25-3p, miR-27b-3p, miR-485-5p, miR-489, miR-93-5p.
Regulated:miR-100-5p, miR-107, miR-130a-3p, miR-140-5p, miR-17-5p // miR-106a-5p, miR-181b-5p, miR-181c-5p, miR-182-5p, miR-206, miR-495-3p.
Estrogen Receptor-Dependent:
Upregulated:miR-21-5p.
Downregulated:miR-181d, miR-193b-3p, miR-200a-3p, miR-200c-3p, miR-203a, miR-26a-5p, miR-26b-5p, miR-27a-3p, miR-27b-3p.
Regulated: let-7a-5p, let-7c, let-7f-5p, let-7g-5p, miR-181a-5p, miR-181b-5p, miR-98-5p.
miRNAs with Known Functions Related to Breast Cancer:let-7i-5p, miR-100-5p, miR-107, miR-10a-5p, miR-10b-5p, miR-125b-5p, miR-130a-3p, miR-132-3p, miR-140-5p, miR-141-3p, miR-148a-3p, miR-152, miR-155-5p, miR-15a-5p, miR-15b-5p, miR-16-5p, miR-17-5p // miR-106a-5p, miR-181d, miR-182-5p, miR-186-5p, miR-193b-3p, miR-199a-3p // miR-199b-3p, miR-200b-3p, miR-200c-3p, miR-204-5p, miR-205-5p, miR-206, miR-21-5p, miR-210, miR-212-3p, miR-22-3p, miR-222-3p, miR-25-3p, miR-27a-3p, miR-27b-3p, miR-29a-3p, miR-31-5p, miR-328, miR-429, miR-485-5p, miR-489, miR-495-3p, miR-7-5p, miR-93-5p, miR-96-5p.
miRNAs Predicted to Regulate Breast Cancer Genes:miR-1, miR-129-5p, miR-195-5p, miR-340-5p, miR-548c-3p, miR-607, miR-613.
Other miRNAs:let-7b-5p, let-7d-5p, let-7e-5p, miR-125b-1-3p, miR-130b-3p, miR-145-5p, miR-18a-5p, miR-19a-3p, miR-19b-3p, miR-199a-5p, miR-20a-5p, miR-20b-5p, miR-202-3p, miR-214-3p, miR-223-3p, miR-29b-3p, miR-29c-3p, miR-424-5p, miR-497-5p.