APPD,凋亡诱导蛋白D抗体

产品编号HZ-6793R
英文名称APPD
中文名称凋亡诱导蛋白D抗体
别 名PKHF1_HUMAN; Apoptosis inducing protein D; LAPF; Lysosome associated apoptosis inducing protein containing PH and FYVE domains; MGC4090; PH and FYVE domain containing protein 1; PH domain containing family F member 1; Phafin 1; Pleckstrin homology domain containing family F (with FYVE domain) member 1; Pleckstrin homology domain containing family F member 1; Pleckstrin homology domain containing family F with FYVE domain member 1; PLEKHF1; ZFYVE15; Zinc finger FYVE domain containing protein 15.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
APPD,凋亡诱导蛋白D抗体研究领域细胞生物 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
产品应用IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human APPD/LAPF (75-124aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
APPD,凋亡诱导蛋白D抗体PubMedPubMed
产品介绍background:
APPD is a lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF). It is a representative of a novel family of PH and FYVE domain-containing proteins and induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway. Cellular localization: Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.

Function:
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.

Subcellular Location:
Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis.

Tissue Specificity:
Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.

APPD,凋亡诱导蛋白D抗体DISEASE:

Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 PH domain.

Gene ID:
79156

Database links:
Entrez Gene: 79156 Human
Entrez Gene: 72287 Mouse
Entrez Gene: 308543 Rat
SwissProt: Q96S99 Human
SwissProt: Q3TB82 Mouse
SwissProt: Q68FU1 Rat
Unigene: 466383 Human
Unigene: 58389 Human
Unigene: 333798 Mouse
Unigene: 9380 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片