FITC标记的肥大细胞类胰蛋白酶β2
产品名称： FITC标记的肥大细胞类胰蛋白酶β2
英文名称： Anti-TPSB2/FITC
产品编号： HZ-20844R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TPSB2/FITC Conjugated antibody
FITC标记的肥大细胞类胰蛋白酶β2
| 英文名称 | Anti-TPSB2/FITC |
| 中文名称 | FITC标记的肥大细胞类胰蛋白酶β2 |
| 别 名 | Tryptase beta-2; Tryptase-2; Tryptase II; TPS2; AV011504; Mcp-6; MCPT6; MMCP-6; TPS2; TPSB2; TRYPTASE 2; TRYPTASE BETA/II; tryptaseB; tryptaseC; tryptase beta-2 precursor; tryptase beta 2 (gene/pseudogene); TRYB1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TPSB2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity). Subunit: Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6. Subcellular Location: Secreted. Similarity: Belongs to the peptidase S1 family. Tryptase subfamily. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 64499 Human Omim: 191081 Human SwissProt: P20231 Human Unigene: 405479 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 类胰蛋白酶（Tryptase）广泛分布于呼吸道和胃肠道、皮肤等组织中，主要用于呼吸系统、胃肠道系统疾病和其肿瘤的研究 |
类胰蛋白酶包括胰蛋白酶样丝氨酸蛋白酶家族，肽酶家族S1。类胰蛋白酶仅作为肝素稳定的四聚体具有酶活性，并且对所有已知的内源性蛋白酶抑制剂具有抗性。几个胰蛋白酶基因聚集在染色体16p133上。这些基因的特征是几种不同的特征。它们具有高度保守的3’UTR，在5’侧和3’UTR处含有串联重复序列，这些序列被认为在调节mRNA稳定性中起作用。这些基因在启动子Met密码子的上游有一个内含子，它把转录起始位点和蛋白质编码序列分开。此特征是胰蛋白酶的特征，但在其他基因中是不寻常的。该基因的等位基因具有数量不寻常的序列变异，因此这些等位基因一度被认为是代表两个独立的基因，βII和βIII。类胰蛋白酶在哮*和其他疾病的发病机制中起着中介作用。