CUL4B抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
CUL4B抗体

CUL4B抗体

商家询价

产品名称： CUL4B抗体

英文名称： CUL4BAntibody

产品编号： XY12916-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 CUL4B抗体

Applications
In-house applications ELISA, IHC, IF, IP, WB     Application not tested? Please see our Guarantee.
Published applications IF, IHC, IP, WB Publications 8 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Human, mouse, rat
Images
Prev12NextView more validation data
  • 12916-1-AP;HEK-293 cellsHEK-293 cells were subjected to SDS PAGE followed by western blot with 12916-1-AP(CUL4B antibody) at dilution of 1:1000
  • 12916-1-AP;HeLa cellsIP Result of anti-CUL4B (IP:12916-1-AP, 3ug; Detection:12916-1-AP 1:1000) with HeLa cells lysate 4650ug.
  • 12916-1-AP;human gliomasImmunohistochemical of paraffin-embedded human gliomas using 12916-1-AP(CUL4B antibody) at dilution of 1:100 (under 10x lens)
  • 12916-1-AP;HepG2 cellsImmunofluorescent analysis of HepG2 cells, using CUL4B antibody 12916-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Positive WB detected in HEK-293 cells, HeLa cells, human testis tissue, mouse testis tissue, SH-SY5Y cells
Positive IP detected in HeLa cells
Positive IHC detected in Human gliomas tissue, human testis tissue
Positive IF detected in HepG2 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100
 CUL4B抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen CUL4B fusion protein ag3563 Full name Cullin 4B
Calculated molecular
weight		 913aa,104 kDa Observed molecular 
weight		 102 kDa
GenBank accession 
number		 BC036216 Gene ID (NCBI) 8450
Gene symbol CUL4B Synonyms CUL 4B, CUL4B, cullin 4B, DKFZp686F1470, KIAA0695, MRXHF2, MRXSC, SFM2
Background CUL4B抗体

Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes, including cell cycle progression, transcription, signal transduction and development (PMID: 21816341)(PMID: 21554755). Serving as the scaffold protein, cullins are crucial for the assembly of ligase complexes, which recognize and target various substrates for proteosomal degradation. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), are two members in cullin family with 83% of identity. Mutations in human CUL4B are one of the major causes of X-linked mental retardation. Cul4b knockout mice demonstrated that CUL4B is indispensable for embryonic development in the mouse (PMID: 22606329). CUL4B抗体

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