卵巢癌miRNA的PCR芯片用于研究已知在卵巢癌的发生和进程中差异表达84个 miRNA的表达。这个芯片为癌症研究人员提供了一个方便快速的方式分析卵巢肿瘤发生的最相关的miRNA。妇科癌症中卵巢癌的死亡率最高,部分原因是经常发现在发展的后期阶段。百分之九十的卵巢肿瘤发生在卵巢上皮。上皮卵巢癌根据病理组织分为几个类，最常见的中类(40%)是浆液。基因芯片分析miRNA的表达发现卵巢癌进程的潜在生物标记，许多结果跟进功能研究,发现潜在的特定致癌机制。这个芯片包含的miRNA是通过基因芯片和功能分析显示特异性参与浆液性卵巢癌的miRNA,这些miRNA大体在上皮性卵巢癌或卵巢癌上。这个芯片的分析结果助于进一步了解卵巢癌发病背后的分子机制。每张芯片含一个对照组使得分析数据时可以用相对定量ΔΔCT方法评估逆转录效率,基因组DNA污染,和PCR效率。利用这张芯片，通过实时定量PCR，可以简易且可靠地分析卵巢癌相关miRNA的表达。

miScript miRNA PCR芯片仅用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。

提供96孔板——384 -(4 x 96)板,和100孔板

Serous Ovarian Cancer:
Upregulated:miR-141-3p, miR-16-5p, miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-21-5p, miR-27a-3p, miR-429, miR-93-5p.
Downregulated:let-7b-5p, miR-100-5p, miR-10b-5p, miR-125b-5p, miR-143-3p, miR-145-5p, miR-214-3p, miR-26a-5p, miR-29a-3p, miR-34b-3p, miR-432-5p, miR-514a-3p, miR-99a-5p.
Regulated:miR-199a-3p // miR-199b-3p.

Epithelial Ovarian Cancer:
Upregulated:miR-141-3p, miR-182-5p, miR-195-5p, miR-199a-3p // miR-199b-3p, miR-200a-3p, miR-200c-3p, miR-203a, miR-205-5p, miR-21-5p, miR-26a-5p, miR-302b-5p, miR-325, miR-373-3p.
Downregulated:let-7a-5p, let-7b-5p, let-7c, let-7d-5p, let-7i-5p, miR-1, miR-100-5p, miR-125b-5p, miR-125b-1-3p, miR-126-3p, miR-133a, miR-140-5p, miR-143-3p, miR-145-5p, miR-152, miR-155-5p, miR-15a-5p, miR-204-5p, miR-22-3p, miR-221-3p, miR-222-3p, miR-224-5p, miR-29a-3p, miR-29c-3p, miR-30a-5p, miR-30a-3p, miR-302b-3p , miR-34b-3p, miR-346, miR-365a-3p, miR-370, miR-375, miR-376a-3p, miR-377-3p, miR-379-5p, miR-410, miR-424-5p, miR-432-5p, miR-492, miR-507, miR-514a-3p, miR-519d, miR-519e-3p, miR-520e , miR-9-5p, miR-99a-5p.
Regulated:miR-101-3p, miR-103a-3p, miR-105-5p, miR-134, miR-137, miR-147a, miR-154-5p, miR-154-3p, miR-199a-5p, miR-200b-3p, miR-211-5p, miR-214-3p.

Ovarian Cancer:
Upregulated:miR-125b-1-3p, miR-140-5p, miR-152, miR-199a-3p // miR-199b-3p, miR-199a-5p, miR-200b-3p, miR-200c-3p, miR-214-3p, miR-22-3p, miR-221-3p, miR-223-3p, miR-29a-3p, miR-29c-3p, miR-30a-5p, miR-30e-5p, miR-365a-3p, miR-370, miR-487b, miR-519e-3p, miR-520e, miR-637, miR-99a-5p.
Downregulated:let-7a-5p, let-7b-5p, let-7c, let-7d-5p, let-7i-5p, miR-125b-5p, miR-134, miR-154-3p, miR-155-5p, miR-195-5p, miR-203a, miR-206, miR-21-5p, miR-335-5p, miR-346, miR-493-3p, miR-507, miR-514a-3p.
Regulated:miR-100-5p, miR-106b-5p, miR-141-3p, miR-15a-5p, miR-200a-3p, miR-222-3p, miR-34b-3p, miR-424-5p.

miRNAs with Known Functions in Ovarian Cancer:let-7i-5p, miR-100-5p, miR-10b-5p, miR-125b-5p, miR-126-3p, miR-133a, miR-140-5p, miR-141-3p, miR-152, miR-155-5p, miR-15a-5p, miR-16-5p, miR-182-5p, miR-199a-3p // miR-199b-3p, miR-200b-3p, miR-200c-3p, miR-204-5p, miR-205-5p, miR-206, miR-21-5p, miR-22-3p, miR-221-3p, miR-222-3p, miR-224-5p, miR-27a-3p, miR-29a-3p, miR-30a-3p, miR-30e-5p, miR-335-5p, miR-34b-3p, miR-373-3p, miR-375, miR-376a-3p, miR-410, miR-429, miR-432-5p, miR-487b, miR-493-3p, miR-637, miR-93-5p.