DBC2,乳腺癌基因删除蛋白2抗体

产品编号HZ-4274R
英文名称DBC2
中文名称乳腺癌基因删除蛋白2抗体
别 名DBC 2; Deleted in breast cancer 2; Deleted in breast cancer 2 gene protein; E130206H14Rik; KIAA0717; p83; RBT2; RHBT2_HUMAN; Rho related BTB domain containing 2; Rho related BTB domain containing protein 2; Rho-related BTB domain containing 2; Rho-related BTB domain-containing protein 2; RHOBTB 2; Rhobtb2.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse,
DBC2,乳腺癌基因删除蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量83kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DBC2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DBC2,乳腺癌基因删除蛋白2抗体PubMedPubMed
产品介绍background:
DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has been implicated as a tumor suppressor in breast and lung cancer. Studies have shown that DBC2 binds to the ubiquitin ligase scaffold Cul3, and that Cul3 regulates DBC2 protein levels by ubiquitinating DBC2 directly, leading to its degradation by the proteasome.

Tissue Specificity:
Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.

Similarity:
Belongs to the small GTPase superfamily. Rho family.
Contains 2 BTB (POZ) domains.

Database links:
UniProtKB/Swiss-Prot: Q9BYZ6.2

DBC2,乳腺癌基因删除蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.