CD274,程序性死亡配体1抗体

产品编号HZ-1103R
英文名称CD274
中文名称程序性死亡配体1抗体
别 名CD274; Programmed cell death 1 ligand 1; Programmed death ligand 1; PD-L1; PDCD1 ligand 1; B7 homolog 1; B7-H1; Programmed death ligand 1; PD1L1_Mouse.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
CD274,程序性死亡配体1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse B7-H1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD274,程序性死亡配体1抗体PubMedPubMed
产品介绍background:
Programmed cell death 1 ligand 1(Programmed death ligand 1；PD-L1; PDCD1 ligand 1; B7 homolog 1; B7-H1; CD274) involved in the costimulatory signal, essential for T lymphocyte proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibit T-cell proliferation and cytokine production.

Function:
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Subunit:
Interacts with PDCD1.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
60533

CD274,程序性死亡配体1抗体Database links:
Entrez Gene: 29126 Human
Entrez Gene: 60533 Mouse
Entrez Gene: 499342 Rat
Omim: 605402 Human
SwissProt: Q9NZQ7 Human
SwissProt: Q9EP73 Mouse
Unigene: 521989 Human
Unigene: 245363 Mouse
Unigene: 228198 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.