CD239,B细胞粘附分子CD239抗体

产品编号HZ-7546R
英文名称CD239
中文名称B细胞粘附分子CD239抗体
别 名Antigen identified by monoclonal antibody F8; AU antibody Auberger B antigen; B CAM cell surface glycoprotein; B cell adhesion molecule; B-CAM cell surface glycoprotein; Basal cell adhesion molecule; Basal cell adhesion molecule Lu and Au blood groups; Basal cell adhesion molecule Lutheran blood group; Bcam; BCAM_HUMAN; CD239; CD239 antigen; F8/G253 antigen; Glycoprotein 95kDa; LU; Lutheran; Lutheran antigen; Lutheran blood group (Auberger b antigen included); Lutheran blood group Auberger b antigen included; Lutheran blood group glycoprotein; MSK19.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 信号转导 细胞膜受体 细胞粘附分子 细胞表面分子 血管内皮细胞
抗体来源Rabbit
克隆类型Polyclonal
CD239,B细胞粘附分子CD239抗体交叉反应Human, Mouse, Rat, Dog, Cow,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量64kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD239
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD239,B细胞粘附分子CD239抗体PubMedPubMed
产品介绍background:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

Function:
Laminin alpha-5 receptor. May mediate intracellular signaling.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

Post-translational modifications:
Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.

Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Gene ID:
4059

CD239,B细胞粘附分子CD239抗体Database links:
Entrez Gene: 4059 Human
Entrez Gene: 57278 Mouse
Entrez Gene: 78958 Rat
Omim: 612773 Human
SwissProt: P50895 Human
SwissProt: Q9R069 Mouse
SwissProt: Q9ESS6 Rat
Unigene: 625725 Human
Unigene: 29236 Mouse
Unigene: 7003 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.