FITC标记的载脂蛋白B-mRNA编辑酶复合物3B抗体
产品名称： FITC标记的载脂蛋白B-mRNA编辑酶复合物3B抗体
英文名称： Anti-APOBEC3B/FITC
产品编号： HZ-12494R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-APOBEC3B/FITC Conjugated antibody
| FITC标记的载脂蛋白B-mRNA编辑酶复合物3B抗体 |
| 英文名称 | Anti-APOBEC3B/FITC |
| 中文名称 | FITC标记的载脂蛋白B-mRNA编辑酶复合物3B抗体 |
| 别 名 | APOBEC1L; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3B; apolipoprotein B mRNA editing enzyme, catalytic;ARCD3; ARP4; bK150C2.2; Cytidine deaminase; DJ742C19.2; FLJ21201; Phorbolin 1 related protein; Phorbolin 2; Phorbolin 2/3; Phorbolin 3; PHRBNL; Probable DNA dC>dU editing enzyme APOBEC3B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APOBEC3B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. APOBEC3 proteins are thought to be RNA editing enzymes and have roles in cell growth. APOBEC3B, also known as phorbolin-1-related protein or phorbolin-2/3, is a 382 amino acid protein belonging to the cytidine and deoxycytidylate deaminase family. APOBEC3B lacks cytidine deaminase activity on RNA molecules, but has been shown to bind to apoB and AU-rich RNAs. APOBEC3B forms a homodimer and interacts with APOBEC3G. APOBEC3B is expressed at at moderate levels in heart, testis, thymus, prostate, ovary, spleen and peripheral blood leukocytes. Function: APOBEC3B is a member of the cytidine deaminase gene family. However, it lacks cytidine deaminase activity, at least on RNA molecules (monomeric nucleoside substrates or synthetic apoB, NF1 and NAT1 RNA template). It binds to apoB and AU-rich RNAs. It is unable to reduce HIV-1 infectivity in vitro. Subunit: Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1. Subcellular Location: Nucleus. Tissue Specificity: Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. Similarity: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Belongs to the cytidine and deoxycytidylate deaminase family. Contains 2 CMP/dCMP deaminase zinc-binding domains Database links: Entrez Gene: 9582 Human Entrez Gene: 315137 Rat Omim: 607110 Human SwissProt: Q9UH17 Human SwissProt: P60705 Rat Unigene: 226307 Human Unigene: 658626 Human Unigene: 29180 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ApOBEC蛋白通过脱毒病毒RNA和DNA胞嘧啶残基抑制逆转录病毒。七个ApObEC3基因或假基因存在于由22号染色体上的基因复制导致的集群中。APOBEC3蛋白被认为是RNA编辑酶，在细胞生长中起着重要的作用。APOBEC3B又称佛波蛋白-1相关蛋白或佛波蛋白-2/3，是属于胞苷和脱氧胞苷脱氨酶家族的382个氨基酸。APOBEC3B缺乏RNA分子上的胞苷脱氨酶活性，但已被证明与ApOb和AU rich RNAs结合。APOBEC3B与APOBEC3G相互作用，在心脏、睾丸、胸腺、前列腺、卵巢、脾脏和外周血白细胞中呈中度表达。